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Research Interests
Optics in medicine, biomedical imaging to guide cancer therapy; dose imaging in radiation therapy; Cherenkov light imaging
Education
- Bc, Czech Technical University 2008
- MSc, Czech Technical University 2010
- PhD, Biomedical Physics, Czech Technical University 2014
Awards
- Best in Physics‘ Imaging Award for "3D Cherenkov Sheet Molecular Imaging provides 100 micron whole body spatial resolution," American Association of Physicists in Medicine (AAPM) Annual Meeting, 2017.
Research Projects
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Exploring the role of oxygen in ultra high dose rate radiotherapy
Exploring the role of oxygen in ultra high dose rate radiotherapy
Ultra-high dose rate (UHDR) radiotherapy (RT) is an emerging cancer treatment that delivers high-energy beams (>40 Gy/s) to target tumors. Unlike conventional radiotherapy, which can damage healthy tissue, UHDR RT has been shown to spare normal tissue while maintaining tumor-killing effectiveness—a phenomenon known as the FLASH effect. The underlying mechanisms of this effect remain unclear. Our research focuses on investigating the role of oxygen in the FLASH effect using optical methods to measure tissue oxygen levels in real time during treatment.
Selected Publications
- BW Pogue, J Feng, EP LaRochelle, P Brůža, H Lin, R Zhang, JR Shell, et al. Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging. Nature Biomedical Engineering 2(4), 254, 2018.
- T Gorkhover, A Ulmer, K Ferguson, M Bucher, F Maia, J Bielecki, T Ekeberg, MF Hantke, BJ Daurer, C Nettelblad, J Andreasson, A Barty, P Brůža, et al. Femtosecond X-ray Fourier holography imaging of free-flying nanoparticles. Nature Photonics 12(3), 150, 2018.
- JD Koralek, JB Kim, P Brůža, CB Curry, Z Chen, HA Bechtel, AA Cordones, P Sperling, S Toleikis, JF Kern, SP Moeller, SH Glenzer, DP DePonte. Generation and characterization of ultrathin free-flowing liquid sheets. Nature Communications 9(1), 1353, 2018.
- P Brůža, SL Gollub, JM Andreozzi, II Tendler, BB Williams, LA Jarvis et al. Time-gated scintillator imaging for real-time optical surface dosimetry in total skin electron therapy. Physics in Medicine and Biology 63(9):095009, 2018.
- JM Andreozzi, KE Mooney, P Brůža, A Curcuru, DJ Gladstone, BW Pogue, O Green. Remote Cherenkov Imaging Based Quality Assurance of a Magnetic Resonance Image Guided Radiotherapy System. Medical Physics, 2018.
- P Brůža, JM Andreozzi, DJ Gladstone, LA Jarvis, J Rottmann, BW Pogue. Online Combination of EPID & Cherenkov Imaging for 3-D Dosimetry in a Liquid Phantom. IEEE Transactions on Medical Imaging 36(10), 2099-2103, 2017.
- P Brůža, H Lin, SA Vinogradov, LA Jarvis, DJ Gladstone, BW Pogue. Light sheet luminescence imaging with Cherenkov excitation in thick scattering media. Optics Letters 41(13), 2986-2989, 2016.
- P Brůža, D Pánek, M Vrbová, V Fidler, C Rose-Petruck. Spatial frequency heterodyne imaging in the soft x-ray water window. Applied Physics Letters 104(25), 254101, 2014.
- P Brůža, V Fidler, M Nikl. Table-top instrumentation for time-resolved luminescence spectroscopy of solids excited by nanosecond pulse of soft X-ray source and/or UV laser. Journal of Instrumentation 6(09), P09007, 2011.
Patents
- Dosimetry systems for radiation treatment using radiation-detector-triggered cameras to image cherenkov emissions or thin-sheet scintillators | 11633627
Videos
Transforming the Future of Cancer Care with Optical Imaging (Seminar)
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