David J. Gladstone

Research Interests

Ultra conformal radiation therapy; image guided radiation therapy; biological gating of therapeutic X-ray beams; image guided brachytherapy; cherenkov emission during radiotherapy; EPR dosimetry

Education

• BSCh, University of Denver 1983
• ScD, Massachusetts Institute of Technology 1989

Professional Activities

• EPR Center, Geisel School of Medicine

Research Projects

• Scintillation dosimetry for quality assurance in radiotherapy

  Scintillation dosimetry for quality assurance in radiotherapy

  Radiation therapy is used to treat cancer tumors by killing the tissue with high ionizing radiation doses. Modern external beam radiotherapy systems deliver high dose levels to precisely marked tumor volume in less time. As a mis-administration can have potentially severe impact to the surrounding healthy tissue, more stringent and complex quality assurance measurements are required in clinics. By developing a comprehensive optical dose imaging camera system, we aim to fundamentally simplify the quality assurance process and, in turn, to further promote the culture of safety in radiotherapy. By converting the dose to visible light using scintillation phantom, we can image and reconstruct 3D dose maps in real time, enabling complete and accurate verification in a fast enough timeframe for it to be useful in every procedure.

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Selected Publications

• Gladstone DJ, Flanagan MF, Southworth JB, Hadley VE, Thibault MW, Hug EB, Hoopes PJ. (2004) "Radiation-Induced Cardiomyopathy as a Function of Radiation Beam Gating to the Cardiac Cycle." Physics in Medicine and Biology. 49: 1475-82.
• Swartz HM, Flood AB, Williams BB, Dong R, Swarts SG, He X, Grinberg O, Sidabras J, Demidenko E, Gui J, Gladstone DJ, Jarvis LA, Kmiec MM, Kobayashi K, Lesniewski PN, Marsh SD, Matthews TP, Nicolade RJ, Pennington PM, Raynolds T, Salikhov I, Wilcox DE, Zaki BI. (2012) "Electron Paramagnetic Resonance Dosimetry for a Large-Scale Radiation Incident." Health Physics. 103(3): 255-67.
• Glaser AK, Davis SC, McClatchy M, Zhang R, Pogue BW, Gladstone DJ. (2013) "Projection Imaging of Photon Beams by the Cerenkov Effect." Medical Physics. 40(1): 012101-1-14.
• Glaser AK, Voigt WHA, Davis SC, Zhang R, Gladstone DJ, Pogue BW. (2013) "Three-Dimensional Cerenkov Tomography of Energy Deposition from Ionizing Radiation Beams." Optics Letters. 38(5): 634-636.
• Zhang R, Davis SC, Demers JH, Glaser AK, Gladstone DJ, Esipova TV, Vinogradov SA, Pogue BW. (2013) "Oxygen Tomography by Cerenkov-Excited Phosphorescence During External Beam Irradiation." Journal of Biomedical Optics. 18(5): 050503-1.
• Jarvis LA, Zhang R, Gladstone DJ, Jiang S, Hitchcock W, Friedman OD, Glaser AK, Jermyn M, Pogue BW. (2014) "Cherenkov Video Imaging Allows for the First Visualization of Radiation Therapy in Real Time." International Journal of Radiation Oncology, Biology, Physics. https://doi.org/10.1016/j.ijrobp.2014.01.046.
• Hoopes PJ, Wagner R, Duval K, Kang K, Gladstone DJ, Moodie K, Cary-Burney M, Ariaspulido H, Veliz F, Steinmetz N, Fiering S. (2018) "Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation." Molecular Pharmaceutics. PMID: 29613803.
• Hachadorian RL, Bruza P, Jermyn M, Gladstone DJ, Pogue BW, Jarvis LA. (2020) "Imaging Radiotherapy Dose Using X-Ray CT Calibration of Cherenkov Light." Nature Communications. 11(1): 2298. PMID: 32385233.
• Rahman M, Ashraf MR, Zhang R, Bruza P, Dexter CA, Thompson L, Cao X, Williams BB, Hoopes PJ, Pogue BW, Gladstone DJ. (2021) "Electron FLASH Delivery at Treatment Room Isocenter for Efficient Reversible Conversion of a Clinical LINAC." International Journal of Radiation Oncology, Biology, Physics. https://doi.org/10.1016/j.ijrobp.2021.01.011. PMID: 33444695.
• Pogue BW, Zhang R, Gladstone DJ. (2021) "A Roadmap for Research in Medical Physics via Academic Medical Centers: The DIVERT Model." Medical Physics. https://doi.org/10.1002/mp.14849. PMID: 33735472.
• Alexander DA, Bruza P, Rassias AG, Andreozzi JM, Pogue BW, Zhang R, Gladstone DJ. (2021) "Visual Isocenter Position Enhanced Review (VIPER): A Cherenkov Imaging-Based Solution for MR-Linac Daily QA." Medical Physics. https://doi.org/10.1002/mp.14892. PMID: 33887796.
• Clark MA, Tavakkoli AD, Petusseau AF, Scorzo AV, Kheirollah A, Davis SC, Strawbridge RR, Bruza P, Pogue BW, Gladstone DJ, Hoopes PJ. (2024) "Dynamic Oxygen Assessment Techniques Enable Determination of Anesthesia's Impact on Tissue." Research Square [Preprint]. https://doi.org/10.21203/rs.3.rs-4751349/v1. PMID: 39257989; PMCID: PMC11384820.

Courses

• ENGS 167: Medical Imaging

News

Welcome: New Faculty
Dec 01, 2021

Dartmouth Engineering Welcomes Seven New Faculty
Oct 18, 2021

Dartmouth Team Invited to Share Promising Findings in Radiation Oncology at National Conference
Sep 28, 2021

Dartmouth Researchers Pilot Safer Method of Radiation Cancer Therapy
Jan 19, 2021

Piloting a FLASH Radiotherapy Beam Development for Treatment of Cancer
Sep 04, 2020

Scientists Capture for First Time, Light Flashes from Human Eye During Radiotherapy
Jan 09, 2020