Research Interests

Biomedical imaging; functional neuroimaging; magnetic nanoparticle imaging

Education

  • AB, Engineering Sciences, Dartmouth 1997
  • BE, Engineering Sciences, Dartmouth 1998
  • SM, Engineering Sciences, Harvard 2001
  • PhD, Engineering Sciences, Harvard 2004

Awards

  • Derek Bok Award for Distinction in Teaching, Harvard 2002

Professional Activities

  • Member, IEEE
  • Member, Tau Beta Pi

Startups

Research Projects

  • Magnetic nanoparticle imaging

    Magnetic nanoparticle imaging

    Magnetic nanoparticle imaging is being developed to meet the needs of translational research on the biodistribution of magnetic nanoparticles (MNPs). Emerging nanotechnology platforms promise to deliver new tools to detect, monitor and treat cancer. These nanotechnology platforms offer a future of personalized medicine where a nanocarrier can be targeted to specific cancer cells, carry a drug payload, be remotely activated at a specific location in the body or upon targeted binding to selected cell types, imaged in-real time, and monitored as therapy progresses. Among the many nanocarriers in development, those utilizing MNPs are ideally suited for translational research because of their long history in biomedical research and many practical applications. We have developed an MNP imaging method called nonlinear susceptibility magnitude imaging (nSMI). Our imaging system has the potential for broad use in translational MNP research because of its functional and cost-efficient design.

  • Clinical optical-electric probes

    Clinical optical-electric probes

    Clinical optical-electric probes are being developed for noninvasive simultaneous measurement of blood oxygenation and electrical potential changes associated with brain activity.

  • Neurovascular coupling

    Neurovascular coupling

    Neurovascular coupling refers to the mechanisms that relate evoked neural activity to localized responses by the cerebral vasculature. Better models of this coupling are needed to improve the interpretation of neuroimaging studies and understanding of neurodegenerative disease.

Selected Publications

Patents

  • Method and apparatus for magnetic susceptibility tomography, magnetoencephalography, and taggant or contrast agent detection | 9,395,425
  • System and methods for smoothly inverting one or more faces of a cubical device | 8,753,029
  • System, optode and cap for near-infrared diffuse-optical function neuroimaging | 8,527,035
  • In-bed exercise machine and method of use | 6,270,445
  • In-bed exercise machine and method of use | 6,152,855

Courses

  • ENGS 90: Engineering Design Methodology and Project Completion
  • ENGS 146: Computer-Aided Mechanical Engineering Design
  • ENGS 89: Engineering Design Methodology and Project Initiation

Videos

Design Initiative at Dartmouth

Why Get a Dartmouth PhD in Engineering

Noninvasive Head Probe for Alzheimer's Disease

New Approach to Alzheimer's Disease

Seminar: Advancing Neuroimaging Technology to Study Brain Dynamics

News