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Katie Hixon

Assistant Professor of Engineering

Clinical Assistant Professor of Orthopaedics

Overview

Professor Hixon's research focuses on tissue engineering/regenerative medicine strategies to improve treatment and facilitate healing in patients with congenital and traumatic craniofacial anomalies, as well as those with delayed or failed musculoskeletal healing. Prior to joining the Dartmouth faculty, Hixon earned a PhD in biomedical engineering at Saint Louis University. Her research broadly included tissue engineering scaffold fabrication for the treatment of critical-size defects and craniofacial/maxillofacial congenital conditions. Following this, she completed a postdoctoral position in the Department of Orthopaedic Surgery at Washington University in St. Louis School of Medicine. Here she was awarded the NIH F32 Ruth L. Kirschstein National Research Service Award to study bone healing following fracture and develop a clinically relevant animal model to test therapeutic interventions. Hixon's work will continue to contribute cutting-edge research utilizing orthopaedic and craniofacial models to drive the development of novel tissue engineering/regenerative medicine therapies, impacting dental, oral, craniofacial, and musculoskeletal health.

Research Interests

Tissue engineering; regenerative medicine; biomaterials and scaffolds; craniofacial reconstruction; orthopaedics; critical-size defects; fracture healing

Education

  • BS, Biomedical Engineering, University of Iowa 2014
  • PhD, Biomedical Engineering, Saint Louis University 2018

Awards

  • F32 Ruth L. Kirschstein National Research Service Award (NRSA), 2019–2021
  • Rising Star in Engineering in Health (Columbia University), 2020
  • Society of Women Engineers (SWE) St. Louis Service Award, 2018
  • Graduate Dissertation Fellow (Saint Louis University), 2017–2018
  • Brennan Summer Fellow (Saint Louis University), 2017
  • Outstanding Graduate Student Award (Saint Louis University), 2016

Professional Activities

  • Chair, Education Initiatives Committee, International Section of Fracture Repair (ISFR), ORS (2022-present)
  • Special Issue Guest Editor, Open Access Journal Gels ("Cryogel Scaffolds") (2022)
  • Member, Education Initiatives Committee, International Section of Fracture Repair (ISFR), ORS (2019–present)
  • Member, American Society for Bone and Mineral Research (ASBMR)
  • Member, Biomedical Engineering Society (BMES)
  • Member, Orthopaedic Research Society (ORS)
  • Member, Society of Women Engineers (SWE)
  • Member, American Association for the Advancement of Science (AAAS)

Selected Publications

  • Olevsky LM, Anup A, Jacques M, Keokominh N, Holmgren EP, Hixon KR. Direct Integration of 3D Printing and Cryogel Scaffolds for Bone Tissue Engineering. Bioengineering. (2023) 10(8):889.
  • Robertson EM, Hixon KR, McBride-Gagyi SH, Sell SA. Bioactive impact of manuka honey and bone char incorporated into gelatin and chitosan cryogels in a rat calvarial fracture model. J Biomed Mater Res. (2023) 111(10): 1763-1774.
  • Vesvoranan O, Anup A, Hixon KR. Current Concepts and Methods in Tissue Interface Scaffold Fabrication. Biomimetics. (2022) 7(4):151.
  • McKenzie JA, Galbreath IM, Coello AF, Hixon KR, Silva MJ. VEGFA from osteoblasts is not required for lamellar bone formation following tibial loading. Bone. (2022) 163: 116502.
  • Hixon KR, and Miller AN. Animal Models of Impaired Long Bone Healing and Tissue Engineering‐ and Cell‐based in Vivo Interventions. Journal of Orthopaedic Research. 40.4 (2022): 767–778.
  • Hixon KR, et al. Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model. Journal of Bone and Mineral Research : JBMR. 36.11 (2021): 2243–2257.
  • Hixon KR, Bogner SJ*, Ronning-Arnesen G*, Janowiak Mulligan BE, Sell SA. Investigating Manuka Honey Antibacterial Properties When Incorporated into Cryogel, Hydrogel, and Electrospun Tissue Engineering Scaffolds. Gels: Cryogelation and Cryogels (2019) 5(2): 21. Invited Contribution. PMID: 31003516. (* indicates authors contributed equally)
  • Hixon KR, Lu T, Carletta MN, McBride‐Gagyi SH, Janowiak BE, Sell SA. A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections. J Biomed Mater Res Part B (2018) 106B:1918–1933. PMID: 28960886
  • Alarcon De La Lastra A, Hixon KR, Aryan LM, Banks AN, Hall AF, Sell SA. Dissolvable 3D-Printed Molds for Patient Specific Craniofacial Bone Regeneration. J Funct Biomater (2018) 9(3): 46. PMID: 30042357
  • Haas G, Dunn A, Marcinczyk M, Talovic M, Schwartz M, Scheidt R, Patel A, Hixon KR, Elmashhady H, McBride-Gagyi SH, Sell SA, Garg K. Biomimetic Sponges for regeneration of skeletal muscle following trauma. J Biomed Mater Res A (2018) 107(1): 92-103. PMID: 30394640
  • Hixon KR, Melvin A, Lin AY, Hall AF, Sell SA. Cryogel Scaffolds from Patient-Specific 3D-Printed Molds for Personalized Tissue Engineered Bone Regeneration in Pediatric Cleft-Craniofacial Defects. J Biomater Appl (2017) 32(5):598-611. PMID: 28980856
  • Hixon KR, Lu T, McBride-Gagyi SH, Janowiak BE, Sell SA. A Comparison of Tissue Engineering Scaffolds Incorporated with Manuka Honey of Varying UMF. Biomed Res Int (2017). PMID: 28326322

Courses

  • ENGS 164: Tissue Engineering
  • ENGS 56: Introduction to Biomedical Engineering
  • ENGS 57: Intermediate Biomedical Engineering
  • ENGS 169: Intermediate Biomedical Engineering

Videos

Rebuilding bone after cancer treatment

Research Quick Takes

Anisia Tiplea with her research poster

Nov 08, 2024

BMES Annual Meeting

At the 2024 Biomedical Engineering Society (BMES) Annual Meeting in Baltimore, MS student Anisia Tiplea '24 presented her senior honors thesis, and Hixon Lab gave an invited talk on their bone regeneration work​​​ supported by the Dartmouth Innovations Accelerator for Cancer.

The inflammatory response in bone

Jan 18, 2024

Embracing Ethical Research

First-year PhD student Amritha Anup Th'23 is first author of "Embracing ethical research: Implementing the 3R principles into fracture healing research for sustainable scientific progress" published in the Journal of Orthopaedic Research. Anup and her international co-authors, as well as professor Katie Hixon, explore recent advances "to replace, reduce, and refine [3R] animal experiments in musculoskeletal, bone, and fracture healing research."

Biosensors figure

Jan 11, 2024

3D-Printed Tissue-Integrated Biosensors

Researchers Anand Tiwari and Sreejith Panicker, PhD students Julia Huddy and Md Saifur Rahman, and Professors Will Scheideler and Katie Hixon coauthored "Biocompatible 3D Printed MXene Microlattices for Tissue-Integrated Antibiotic Sensing" published in Advanced Materials Technologies. The study developed new electrode materials for 3D-printed porous electrochemical biosensors to monitor antibiotic release in tissue engineering scaffolds.

Adelaide Cagle presenting

Nov 16, 2023

Global Conference on Osseointegration

Hixon Lab member and PhD Innovation fellow (surgical track) Adelaide Cagle attended the Global Collaborative Congress on Osseointegration in Charlotte, NC. Hers was chosen from a large group of abstracts for an oral presentation entitled "Tissue-Engineered Combination Construct for Osseointegration Support" and complimented as one of the best presentations at the conference.

Adelaide Cagle with her poster

Oct 26, 2023

Biomedical Engineering Society Annual Meeting

The Hixon Lab attended the national Biomedical Engineering Society (BMES) Annual Meeting in Seattle, WA. PhD student Peter Bertone and Research Assistant Sree Panicker gave oral presentations on bone oncology and electrically-stimulated bone formation, respectively. PhD students Adelaide Cagle and Levi Olevsky gave poster presentations on dermal adhesion and craniofacial reconstruction, respectively.

Karina Mitchell '23 with her poster

Apr 20, 2023

Students Present at TERMIS Conference

Hixon Lab undergrads Karina Mitchell '23 and Rosemary (Posie) Millett '25 presented their original research at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) Conference in Boston last week. Karina presented her poster on Manuka honey in tissue-engineered scaffolds, and Posie gave an oral presentation on combined tissue-engineered scaffolds targeting the bone-tendon attachment site.