Research

Jiwon Lee

Ralph and Marjorie Crump Assistant Professor of Engineering

Professor Lee with PhD candidate Nicholas Curtis and research associate Seungmin Shin in the Lee Lab at Dartmouth-Hitchcock's Williamson Translational Research Building. (Photo by Mark Washburn)

Research Interests

Antibody repertoire profiling; systems immunology; protein engineering; vaccine designs

Education

BA, Molecular & Cell Biology, University of California, Berkeley 2009
PhD, Chemical Engineering, University of Texas, Austin 2016

Selected Publications

Lee, J. and Georgiou, G. Understanding humoral responses in the gut to Klebsiella pneumoniae microbial glycan. Nat. Immunol. 19, 514-515 (2018).
Chen, Y., Wohlbold, T.J., Zheng, N., Huang, M., Huang, Y., Neu, K.E., Lee, J., Wan, H., Rojas, T., Kirkpatrick, E., Henry, C., Palm, A.E., Stamper, C.T., Lan, L.Y., Topham, D.J., Treanor, J., Wrammert, J., Ahmed, R., Eichelberger, M.C., Georgiou, G., Krammer, F., and Wilson, P.C. Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies. Cell 173, 417-429 (2018).
Wang, B., DeKosky, B.J., Timm, M.R., Lee, J., Normandin, E., Misasi, J., Kong, R., McDaniel, R.M., Delidakis, G., Leigh, K.E., Niezold, T., Choi, C.W., Viox, E.G., Fahad, A., Cagigi, A., Ploquin, A., Leung, K., Yang, E.S., Kong, W., Voss, W.N., Schmidt, A.G., Moody, M.A., Ambrozak, D.R., Henry, A.R., Laboune, F., Ledgerwood, J.E., Graham, B.S., Connors, M., Douek, D.C., Sullivan, N.J., Ellington, A.D., Mascola, J.R., and Georgiou, G. Functional interrogation and mining of natively-paired human VH:VL antibody repertoires. Nat. Biotechnol. 36, 152-155 (2018).
Lee, C., Romain, G., Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee, J., Triplett, K., Donkor, M., Lungu, O.I., Lux, A., Marshall, N.M., Lindorfer, M.A., Goff, O.R., Balbino, B., Kang, K.H., Tanno, H., Delidakis, G., Alford, C., Taylor, R.P., Nimmerjahn, F., Varadarajan, N., Bruhns, P., Zhang, Y.J., and Georgiou, G. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions. Nat. Immunol. 18, 889–898 (2017).
Lee, J., Boutz, D.R., Chromikova, V., Joyce, M.G., Vollmers, C., Leung, K., Horton, A.P., DeKosky, B.J., Lee, C., Lavinder, J.J., Murrin, E.M., Chrysostomou, C., Hoi, K.H., Tsybovsky, Y., Thomas, P.V., Druz, A., Zhang, B., Zhang, Y., Wang, L., Kong, W., Park, D., Popova, L.I., Dekker, C.L., Davis, M.M., Carter, C.E., Ross, T.M., Ellington, A.D., Wilson, P.C., Marcotte, E.M., Mascola, J.R., Ippolito, G.C., Krammer, F., Quake, S.R., Kwong, P.D., and Georgiou, G. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nat. Med. 22, 1456–1464 (2016).
Raymond, D., Stewart, S., Lee, J., Ferdman, J., Bajic, G., Do, K.T., Ernandes, M.J., Suphaphiphat, P., Settembre, E.C., Dormitzer, P.R., Guidice, G.D., Finco, O., Kang, T.H., Ippolito, G.C., Georgiou, G., Kepler, T.B., Haynes, B.F., Moody, M.A., Liao, H., Schmidt, A.G., and Harrison, S.C. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat. Med. 22, 1465–1469 (2016).