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Protein Engineering Research

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Protein engineering research is part of the overall program area of biological and chemical engineering (B&CE) at Dartmouth, using fundamental principles of biology, chemistry, and mathematics to invent bio-inspired systems, circuits, and processes as well as biotherapies and biofuels.

B&CE faculty are committed to building research and educational communities that are high-achieving, impactful, collaborative, and inclusive.

Protein engineering techniques have the potential to redesign nature's biocatalysts at the molecular level and generate novel biomolecules with superior targeted activity. Active projects at Dartmouth include novel protein expression systems, therapeutic protein deimmunization, and vaccine design.

Our collective research activities can be mapped onto a landscape defined by both impact (health and energy), and scale (molecular, cellular, and systems).

Griswold graphic white

Research Subfields

Cell-based protein purification systems

Cellular engineering of protein expression hosts

Glyco-engineering of proteins

Novel protein expression systems

Protein engineering tools in immunology

Therapeutic protein deimmunization

Researchers

Margaret Ackerman headshot Margie Ackerman

Tillman Gerngross headshot Tillman U. Gerngross

Karl Griswold headshot Karl Griswold

Jiwon Lee headshotjpg Jiwon Lee