Margie Ackerman

Research Interests

Protein engineering; biotherapeutics; vaccine technology; engineering immune responses

Education

• BS, MS, Chemistry, Biochemistry, Brandeis University 2003
• PhD, Biology, Massachusetts Institute of Technology 2010

Research Projects

• Protein engineering tools in immunology
• Vaccine design
• Immunogenicity prediction

Selected Publications

• Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines. Chung AW, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S, Dugast AS, Schoen MK, Rolland M, Suscovich TJ, Mahan AE, Liao L, Streeck H, Andrews C, Rerks-Ngarm S, Nitayaphan S, de Souza MS, Kaewkungwal J, Pitisuttithum P, Francis D, Michael NL, Kim JH, Bailey-Kellogg C, Ackerman ME, Alter G. Sci Transl Med. 2014 Mar 19;6(228):228ra38. doi: 10.1126/scitranslmed.3007736. PMID: 24648341 [PubMed - in process]
• Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers. Lai JI, Licht AF, Dugast AS, Suscovich T, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME. J Virol. 2013 Dec 18. [Epub ahead of print] PMID: 24352471 [PubMed - as supplied by publisher]
• Antibody Fc: Linking Adaptive and Innate Immunity. Margaret Ackerman, Falk Nimmerjahn (Editors). Academic Press, Elsevier, 2013 Oct 4. ISBN-10: 0123948029 | ISBN-13: 978-0123948021
• Mapping the journey to an HIV vaccine. Ackerman M, Alter G. N Engl J Med. 2013 Jul 25;369(4):389-91. doi: 10.1056/NEJMcibr1304437. No abstract available. PMID: 23883384 [PubMed - in process]
• Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G. J Clin Invest. 2013 Apr 8. doi:pii: 65708. 10.1172/JCI65708. [Epub ahead of print] PMID: 23563315
• What mAbs Tell Us about Shapes: Multiple Roads Lead to Rome. Alter G, Ackerman ME. Immunity. 2013 Jan 24;38(1):8-9. doi: 10.1016/j.immuni.2013.01.003. PMID: 23352219
• High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples Brown EP, Licht AF, Dugast AS, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME. J Immunol Methods. 2012 Sep 27. pii: S0022-1759(12)00289-X. doi: 10.1016/j.jim.2012.09.007.
• Vaccine design: emerging concepts and renewed optimism. Grimm SK, Ackerman ME. Curr Opin Biotechnol. 2013 Mar 6. doi: pii: S0958-1669(13)00029-3. 10.1016/j.copbio.2013.02.015. [Epub ahead of print] PMID: 23474232

Courses

• ENGG 260: Advances in Biotechnology

Books

Antibody Fc: Linking Adaptive and Innate Immunity

Academic Press, 2013

Videos

News

Dartmouth Researchers Receive Funding Awards to Develop New Vaccines
Oct 03, 2024

Symposium Explores AI Revolution in Health Care
Apr 04, 2024

Dartmouth Researchers Offer New Insights into How Antibodies Function Against HSV
Feb 12, 2024

Dartmouth Hosts First International Vaccine Conference
Dec 07, 2023

New Dartmouth Center Applies AI to Improve Health Outcomes
Jun 05, 2023

Four Engineering Research Projects Win Support from The Dartmouth Innovations Accelerator for Cancer
Jan 24, 2023

Leading Thoughts: A Rich Intellectual Climate
Jul 01, 2022

Milder Cases of COVID-19 Linked to IgA Antibodies
Aug 18, 2020

Rebooting Research, Phase One
May 22, 2020

SYNERGY Announces 2017 Translational Pilot Grant Awards
Apr 03, 2017

Professors Ackerman and Halter Receive Faculty Mentor Awards
Apr 28, 2016

Ragon and Dartmouth collaborate to tailor new vaccine approach against HIV
Dec 20, 2011

In the News