Using high-throughput tools, researchers are studying the antibody response to various diseases and exposures, from infection to cancer, in order to aid in therapeutic and vaccine design and development. We aim to understand the protective mechanism of antibodies using approaches grounded in fundamental engineering principles utilizing protein evolution, molecular biology, and mathematical modeling. Active projects at Dartmouth include immune response profiling, modeling, and modulation, and biotherapeutics and vaccine design.
Our collective research activities can be mapped onto a landscape defined by both impact (health and energy), and scale (molecular, cellular, and systems).
Immune response profiling, modeling, and modulation
Impact of hormones on immune cells
Peripheral correlates of reproductive health
Personalized antibody-based therapeutics
Protein engineering tools in immunology
Vaccine design and development