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Ethan K. Murphy

Ethan K. Murphy

Assistant Professor of Engineering

Overview

My research primarily involves physics-based electrical modeling, imaging electrical properties with a technique called electrical impedance tomography (EIT), and using a combination of computational techniques to improve these methods for practical biomedical applications. Much of my work involves 3D mesh generation for finite element method problems and fusing data from multiple data sources.

Education

  • BS, Mathematics, Worcester Polytechnic Institute 2002
  • MS, Industrial Mathematics, Worcester Polytechnic Institute 2002
  • PhD, Mathematics, Colorado State University 2007

Research Interests

Electrical impedance tomography; data fusion; finite element method (FEM) modeling; noise/data filtering; general numerical methods; magnetic resonance electrical property tomography; electroencephalogram (EEG) source localization

Selected Publications

  • E.K. Murphy, X. Wu, A. Everitt, and R.J. Halter, “Phantom Studies of Fused-data TREIT using only Biopsy-probe electrodes ,” IEEE. Trans. Med. Imag., 2020 (accepted).
  • E.K. Murphy, J. Skinner, M. Martucci, S.B. Rutkove, and R.J. Halter, “Toward Electrical Impedance Tomography Coupled Ultrasound Imaging for Assessing Muscle Health.” IEEE transactions on medical imaging, vol. 38, no. 6, pp.1409-1419, 2018.
  • E.K. Murphy, X. Wu, and R.J. Halter, “Fused-data Transrectal EIT for Prostate Cancer Imaging,” Physiological Measurement, vol. 39, no. 5, p.054005, 2018.
  • E.K. Murphy, A. Mahara, X. Wu, and R.J. Halter, “Phantom Experiments using Soft-Prior Regularization EIT for Breast Cancer Imaging.” Physiological Measurement, vol. 38, no. 6, pps.1262-1277, 2017.
  • E.K. Murphy, A. Mahara, S. Khan, E.S. Hyams, A.R. Schned, J. Pettus, and R.J. Halter, “Comparative Study of Separation between ex vivo Prostatic Malignant and Benign Tissue using Electrical Impedance Spectroscopy and Electrical Impedance Tomography.” Physiological Measurement, vol. 38, no. 6, pps.1242-1261, 2017.
  • E.K. Murphy, A. Mahara, and R.J. Halter, “Absolute Reconstructions using Rotational Electrical Impedance Tomography for Breast Cancer Imaging.” IEEE Trans. on Med. Img., vol. 36, no. 4, pp.892-903, 2017.
  • E.K. Murphy, A. Mahara, and R.J. Halter, “A Novel Regularization Technique for Microendoscopic Electrical Impedance Tomography.,” IEEE Trans. Med. Imaging, vol. 35, no. 7, pp. 1593–1603, 2016.
  • V Brovko, E.K. Murphy, and V.V Yakovlev, “Waveguide Microwave Imaging : Solids Volume Fraction of Particulate Materials,” Appl. Comput. Electromagn. Soc. J., vol. 30, no. 11, pp. 1161–1167, 2015.
  • E.K. Murphy and V.V. Yakovlev, “Neural Network Optimization of Complex Microwave Structures with a Reduced Number of Full-Wave Analyses,” International Journal of RF & Microwave Computer-Aided Engineering, Vol. 21, No. 2, pp. 279-287, 2011.
  • E.K. Murphy and J. L. Mueller. “Effect of Domain Shape Modeling and Measurement Errors on the 2-D D-bar Method for EIT,” IEEE Trans. on Medical Imaging, Vol. 28, pp. 1576–1584, 2009.

Awards

  • PI for NIH R03 (1R03EB027224-01A1) entitled “An Automated-Whole-Breast Ultrasound and Electrical Impedance Tomography System for Improved Breast Cancer Imaging”, 6/19–3/21
  • Clinical Poster Award, Northeast Amyotrophic Lateral Sclerosis Conference, 2019
  • PI for a Phase I STTR entitled “EOIR Debris Management during ascent phase for C2BMC”, for the MDA in 2013.
  • Best Creative Work, Saratov State Technical University 2010 for IEEE Trans. Microwave Theory Tech. paper entitled, “Waveguide Microwave Imaging: Neural Network Reconstruction of Functional 2-D Permittivity Profiles”

Research Projects

  • Electrical impedance imaging for prostate cancer screening

    Electrical impedance imaging for prostate cancer screening

    Electrical impedance imaging for prostate cancer screening is the process of imaging non-invasively the electrical properties (conductivity and permittivity) of the prostate and its vicinity using electrodes mounted onto an intracavitary probe.

  • Imaging muscle properties with combined ultrasound and electrical impedance tomography

    Imaging muscle properties with combined ultrasound and electrical impedance tomography

    Assessing muscle health is important diagnostic information in the treatment of numerous peripheral nerve diseases. This project aims to incorporate spatial information from ultrasound into the inverse problem of electrical impedance tomography in order to accurately image the electrical properties of the muscle (under the skin and adipose tissue).

  • Combined whole breast ultrasound and electrical impedance tomography

    Combined whole breast ultrasound and electrical impedance tomography

    Ultrasound is a supplemental screening technique that has good sensitivity in dense breasts, is inexpensive, and is widely available, but unfortunately, it has high rates of false positives. Electrical impedance tomography (EIT) is a second attractive modality that is low-cost and has shown promise for cancer detection and in differentiating fibrocystic tissues from other tissues. Combining automated whole breast ultrasound (ABUS), which is a recent improvement to standard ultrasound, with EIT may significantly reduce the number of false positives of ABUS. If successful, the combined ABUS/EIT system could become an important screening technology for women with dense breasts.

  • Electrical impedance tomography in pulmonary and cardiac applications

    Electrical impedance tomography in pulmonary and cardiac applications

    The most common application, so far, of electrical impedance tomography (EIT) has been pulmonary monitoring of patients. In particular, we have been pursuing EIT for cardiac output monitoring (a related application) and EIT as a surrogate for pulmonary function tests.