Research Interests

Stereotactic and functional neurosurgery; cancer neurosurgery; intraoperative image-guidance systems; computational modeling; neuroimaging

Education

• AB, Princeton University 1972
• MD, Dartmouth Medical School 1975
• MA, Oxford University 1978

Professional Activities

• Member, American Academy of Neurological Surgery
• Member, American Association of Neurological Surgeons
• Member, AANS/CNS Joint Section on Tumors
• Elected Member, Board of Directors, American Board of Neurological Surgery
• Executive Committee, Vice President, Society of Neurological Surgeons
• Editor, Stereotactic and Functional Neurosurgery
• Editorial Board, Neurosurgical Focus
• Editorial Board, World Neurosurgery
  

Research Projects

• Preoperative image updating for guidance during brain tumor resection

  Preoperative image updating for guidance during brain tumor resection

  The goal of this project is to optimize and validate, in human and animal studies, intraoperative image updating methods that assimilate intraoperative data acquired with stereovision and ultrasound with computational modeling to update preoperative MRI in order to maintain image registration accuracy throughout surgery.

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Selected Publications

• Valdes PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative fluorescence imaging. (Sci Rep. 2012; 2:798. doi: 10.1038/srep00798. Epub 2012 Nov 1)
• Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Songbai J, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD. Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid). (Neurosurg Clin N Am, 2012; 23(3):371-7). PMID: 22758650
• Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Ji S, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD. Adjuncts for Maximizing Resection: 5-ALA. (Clin Neurosurg. 2012; 59:75-8)
• Valdes PA, Leblond F, Kim A, Paulsen KD, Wilson BC, Roberts DW. A spectrally-constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence guided surgery. (Opt Lett. 2012; 37(11):1817-9). PMID: 22660039
• Konecky SD, Owen CM, Rice T, Valdes PA, Kolste K, Wilson BC, Leblond F, Roberts DW, Paulsen KD, Tromberg BJ. Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models. (J Biomed Opt. 2012; 17(5):0506008). PMID: 22612131
• Valdés PA, Moses ZM, Kim A, Paulsen KD, Wilson BC, Roberts DW, Harris BT. Relationship between ex vivo gadolinium concentrations and 5-aminolevulinic acid-induced protoporphyrin IX levels in gliomas: a quantitative study on a relationship between protoporphyrin IX levels and blood-brain barrier breakdown. (J Neuropathol Exp Neurol. 2012; 71(9):806-813). PMID: 22878664
• Valdes PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW. Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. (J Biomedical Optics. 2011; 16(116007)).
• Leblond F, Ovanesyan Z, Davis SC, Valdés PA, Kim A, Wilson BC, Hartov A, Pogue BW, Paulsen KD, Roberts DW. Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral subsurface imaging. (Phys Med Biol, 2011; 56(21): 6823-6837). PMID: 21971201
• Valdes PA, Kim A, Bratsch M, Niu C, Moses Z, Tosteson TD, Wilson BC, Paulsen KD, Roberts DW, Harris BT. δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathological markers of malignancy in human gliomas: the need for quantitative fluorescence guided resection to identify regions of increasing malignancy. (Neuro-Oncology, 2011; 13(8): 846-556). PMID: 21798847
• Bekelis K, Valdes PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW. Quantitative and qualitative ALA-induced PpIX fluorescence in skull base meningiomas. (Neurosurgical Focus, 2011; 30(5): E8). PMID: 21529179

News

Dartmouth Is Helping Brain Surgeons See Tumors More Clearly
Mar 06, 2017

Dartmouth Wins FDA Approval for Aid to Guide Cancer Surgery
Oct 11, 2016