This course will provide a comprehensive introduction to the design, modeling, and experimental implementation of synthetic bio-molecular circuits in living cells at an undergraduate level. Simple but sophisticated synthetic biological circuits will be implemented and tested in microbial cells in the laboratory including those involving molecular amplification, regulatory feedback loops with biological nonlinearities, and robust analog circuits. Computer aided design, modeling, and simulation will use CADENCE, an industry standard electronic circuit design laboratory tool. It will show them how to design, model, and fit actual experimental biological data such that engineering circuit theory and biological experiment agree.
ENGS 22 or Permission of Instructor. Experience in Molecular Biology is useful (e.g. ENGS 35, BIOL 45, & BIOL 46 or equivalent) but not necessary.