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Geoffrey P. Luke

Associate Professor of Engineering

Professor Luke uses the rotary evaporator for nanoparticle synthesis at the Williamson Translational Research Building. (Photo by Kathryn LoConte Lapierre)

Research Interests

Ultrasound imaging; photoacoustic imaging; bionanotechnology; cancer diagnostics and therapy; molecular imaging

Education

  • BS, Computer Engineering and Mathematics, University of Wyoming 2007
  • MS, Electrical Engineering, University of Wyoming 2009
  • PhD, Electrical Engineering, The University of Texas at Austin 2013

Selected Publications

  • GP Luke and SY Emelianov, “Label free detection of lymph node metastases with ultrasound-guided functional photoacoustic imaging,” Radiology, (Published online).
  • GP Luke, JN Myers, SY Emelianov, and KV Sokolov, “Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors,” Cancer Research, volume 74, issue 19, 2014.
  • S Kim, Y-S Chen, GP Luke, and SY Emelianov, “In-vivo ultrasound and photoacoustic image-guided photothermal cancer therapy using silica-coated gold nanorods,” IEEE Trans. Ultrason., Ferroelectr., Freq. Control, volume 61, issue 9, 2014.
  • GP Luke and SY Emelianov, “Optimization of in vivo spectroscopic photoacoustic imaging by smart optical wavelength selection,” Optics Letters, volume 39, issue 7, 2014.
  • AS Hannah, GP Luke, KA Wilson, KA Homan, and SY Emelianov, “Optically-triggered vaporization of ICG-loaded perfluorocarbon nanodroplets for enhanced ultrasound and photoacoustic imaging,” ACS Nano, volume 8, number 1, 2014.
  • GP Luke, A Bashyam, KA Homan, S Makhija, Y-S Chen, and SY Emelianov, “Silica-coated gold nanoplates as stable photoacoustic contrast agents for sentinel lymph node imaging,” Nanotechnology, volume 24, number 45, 2013.
  • GP Luke, SY Nam, and SY Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics, volume 1, issue 2, 2013.
  • GP Luke, DY Yeager, and SY Emelianov, “Biomedical applications of photoacoustic imaging with exogenous contrast agents” Annals of Biomedical Engineering, volume 40, number 2, pp. 422-437, 2012.
  • S Kim, Y-S Chen, GP Luke, and SY Emelianov, “In vivo three-dimensional spectroscopic photoacoustic imaging for monitoring nanoparticle delivery.” Biomedical Optics Express, volume 2, issue 9, 2011.
  • S Mallidi, GP Luke, and S Emelianov, “Role of photoacoustic imaging in cancer detection, diagnosis, and treatment guidance,” Trends in Biotechnology, volume 29 issue 5, 2011.

Courses

  • ENGS 31: Digital Electronics
  • ENGS 120: Electromagnetic Waves: Analytical and Modeling Approaches
  • ENGS 123: Optics

Research Quick Takes

Professor Geoffrey Luke

Oct 03, 2024

NIH Cancer Imaging Award

Professors Geoffrey Luke and Kim Samkoe were awarded a $2.2 million four-year grant from the National Institutes of Health (NIH). "The project is focused on combining ultrasound imaging with tumor-targeted nanodroplets to detect the presence of oral cancer in lymph nodes," says Luke. The research could lead to better diagnosis and fewer surgeries.

Nanodroplets graphic

Jan 11, 2024

Multiplex Ultrasound Imaging

Austin Van Namen Th'21, Sid Jandhyala Th'22, Catalina Spatarelu Th'22, and Professors Kim Samkoe and Geoff Luke are coauthors of "Multiplex Ultrasound Imaging of Perfluorocarbon Nanodroplets Enabled by Decomposition of Postvaporization Dynamics" published in Nano Letters. The paper describes a method to use phase-changing nanodroplets as ultrasound contrast agents for imaging multiple biomarkers simultaneously.