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PhD Thesis Proposal: Ryan Duke



8:00am - 10:00am ET

Auditorium F, DHMC/Online

For Zoom information, contact

"Novel Methods for Image Guided Neurosurgery"


Delicate structures within the central nervous system require precise instrumentation. The current standard of practice to improve outcomes of neurosurgery is through the use of image guidance. Current methods of guidance require accurate and timely imaging to assure precision throughout the procedure. These timely images require intraoperative MRI or CT. The facilities required are often purpose built, can cost upwards of $10,000,000.00, emit radiation, and require specialized staffing. Further increasing the cost to the hospital and ultimately the patient. Image updating methods have been developed with the future goal to reduce cost, and radiation dose from intraoperative CT (iCT) imaging. Image guidance has also been applied to further develop novel genetic tumor models for Glioma research.

The purpose of this thesis proposal is to outline the future work which will be completed as a requirement for the PhD of Ryan Duke. The proposed work includes the following: placement of pedicle screws in a live animal model using a novel semi-rigid deformation model, a retrospective analysis of the errors within image updated pedicle screw placement, optimization of the deformation model used for image updating in pedicle screw placement, creation of a clinical Hand-held Stereovision (HHS) System, and an accuracy assessment of the growth of porcine tumors under image guidance.

Thesis Committee

  • Keith Paulsen (Advisor & Chair)
  • Xiaoyao Fan (Co-Chair)
  • Sohail Mirza
  • Linton Evans
  • Matthieu Chabanas


For more information, contact Theresa Fuller at