Opto-Electro-Chemo Bionic Devices for Biomedical Interfacing
3:30pm - 4:30pm EST
Meeting ID: 926 2343 4275
Biomedical microelectromechanical systems (bioMEMS) enable translational engineering solutions for next-generation diagnosis and therapies to address vital unmet medical needs. In particular, the Microtechnology (µTech) Laboratory at Michigan State University is interested in developing innovative bionic devices based on multiple modalities (e.g. electrical, optical, and chemical) using bioMEMS technologies. These devices form seamless interfaces with biological tissues for potential applications in fundamental neuroscience research, biomedical diagnostics, and therapeutics.
This talk will focus on our recent efforts towards developing hybrid opto-electro-chemo implants at the microscale combining novel inorganic materials with polymeric materials. I will first highlight the development of a wireless opto-μECoG array consists of epidural LEDs and transparent microelectrodes for stimulating and recording neural activity from superficial layers of the cortex. In the second example, an ultra-flexible, highly conductive and transparent microscale electrocorticogram (μECoG) electrode arrays made of PEDOT:PSS-ITO-Ag-ITO assembly are developed for neural recordings in conjunction with optogenetics neuromodulation and imaging. The last example is boron-doped polycrystalline diamond microfiber electrodes for neurotransmitter sensing. The efficacy of the above devices has been demonstrated in-vitro or in-vivo in rat models.
About the Speaker(s)
Associate Professor of Electrical and Computer Engineering and Biomedical Engineering, Michigan State U
Dr. Wen Li is currently an associate professor in the Departments of Electrical and Computer Engineering and Biomedical Engineering, and the Associate Chair for Space Management, Public Relations and Special Initiatives Announcement in the Department of Electrical and Computer Engineering at Michigan State University, East Lansing. Her research interests include bioMEMS, neuroprosthetic devices, micro/nano sensors, nanoelectronics, polymer microfabrication process development, and microsystem integration and packaging technologies. Dr. Li is the recipient of the NSF CAREER Award (2011), the Best Application Paper Award at 3M-NANO (2011), and the Best Paper Award at International Neurotechnology Consortium (2013). She and her team have published over 110 peer-reviewed scientific papers in high impact journals and conferences. She also holds 9 patents and patent applications. Li is on the editorial board of IEEE Transactions on Biomedical Engineering, IET Micro & Nano Letters, and Frontiers in Mechanical Engineering: Micro- and Nano-mechanical Systems. She is also the guest editor for Micromachines special issues on “Implantable Microdevices”, Journal of Micromechanics and Microengineering special issue on “Soft Neural Interfaces”, and Sensors special issue on "Implantable Sensors".
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