2024 Investiture Information

All Thayer Events

Flexible Treatment Plans & Genetic Testing Strategies for Cardiovascular Disease



3:30pm - 4:30pm ET


Meeting ID: 944 1693 8471
Passcode: 681037

Cardiovascular diseases are considered the leading cause of death in the US and worldwide. The management of cardiovascular diseases can be improved by (1) providing physicians and their patients with flexibility in the implementation of protocols, and (2) incorporating novel procedures, such as genetic testing. To benefit from physicians’ opinions and allow for patients’ preferences in the implementation of mathematical models, I introduce a framework that integrates approximate dynamic programming and statistical multiple comparisons to obtain sets of near-optimal treatment choices. By analyzing the structure of the sets, I characterize their behavior with respect to the modeling data and identify when they can be ordered according to the context of the problem. I show how this method can be applied in medical practice by finding hypertension treatment plans for 16.72 million adults in the US.

To understand the clinical and policy implications of genetic testing in cardiovascular diseases, I next present a thoroughly validated simulation model to evaluate the impact of genetic information across different populations in the US. Building upon this work, I illustrate a framework that combines dynamic programming with value of information analysis to simultaneously determine optimal cholesterol treatment and genetic testing decisions. To conclude my talk, I will discuss future opportunities at the intersection of operations research and statistics to support medical decision making in practice.

About the Speaker(s)

Wesley J. Marrero Colon
Postdoctoral Research Fellow, Harvard Medical School

Wesley is a postdoctoral fellow at Harvard Medical School and the Massachusetts General Hospital. His research interest lies at the intersection of operations research and statistics, with an emphasis on stochastic simulation and optimization to support decision making in practice. Wesley’s current work addresses healthcare applications at a population and patient level. Using population-level data, he focuses on modeling the future supply, demand, and allocation of organs for transplantation. Using patient-level data, he develops personalized treatment plans and testing strategies for cardiovascular diseases. Wesley has ongoing collaborations with the University of Michigan Medical School, the University of Michigan School of Public Health, and the US Department of Veterans Affairs.

Wesley is a recipient of the National Science Foundation Graduate Research Fellowship and the Rackham Merit Fellowship. Through his PhD studies, he received the 2020 INFORMS Judith Liebman Award, the 2020 INFORMS Minority Issues Forum best poster award, and the American Statistical Association sponsored best poster award at the 2017 Michigan Student Symposium for Interdisciplinary Statistical Sciences.


For more information, contact Ashley Parker at ashley.l.parker@dartmouth.edu.