Research Interests

Optical spectroscopy and imaging systems for biomedical applications

Education

• BS, Automatic control system, University of Xian Institute of Technology (China)
• MS, Optoelectronics, Fukui University (Japan)
• PhD, Optoelectronics, Tokyo Institute of Technology (Japan) 1992

Awards

• Optical Society of America (OSA) Senior Member
• NIH/NCI: R21: 7/1/2009 - 6/30/2011 (NIR Hypoxia Imaging of Breast Tumor Response to Neoadjuvant Chemotherapy in Vivo)
• NIH/NCI: Mentored quantitative research career development award: 2/23/2005 - 8/31/2009 (Dynamic pressure-enhanced near-infrared breast cancer imaging)

Research Projects

• Near-infrared imaging

  Near-infrared imaging

  Near-infrared imaging (NIR) provides a way to quantify blood and water concentrations in tissue, as well as structural and functional parameters. Since normal tissue, benign tumors, and malignant tumors each carry different concentrations of both hemoglobin and water, and have different levels of oxygen demand and ultrastructural scattering, NIR spectroscopy can be combined into standard imaging systems as an effective method of to provide additional information for breast cancer detection and diagnosis. Work is ongoing to improve techniques for better image reconstruction, display and integration with magnetic resonance imaging (MRI) and computed tomography (CT) imaging.

  See also Center for Imaging Medicine

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• Optical molecular imaging

  Optical molecular imaging

  Optical molecular imaging is being used to provide molecular guidance in cancer surgery. Fluorescent contrast agents are in pre-clinical and clinical studies to image cancer tumors in vivo, with a dual focus, first on getting more accurate information out of the tissue, and secondly to provide better information about the specificity of the molecules as markers. Systems and algorithms for diffuse fluorescence imaging of tissue are studied, both as a stand-alone system, and as coupled to magnetic resonance imaging and computed tomography imaging. Tracer kinetic modeling is also being developed to allow quantitative imaging of molecular binding in vivo.

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• Cerenkov imaging in radiation therapy

  Cerenkov imaging in radiation therapy

  Radiation therapy is used to treat cancer tumors by killing the tissue with high ionizing radiation doses. Until recently it has not been possible to image the radiation dose delivered to tissue, but through Cherenkov light imaging, this delivered dose can be mapped with high resolution cameras. The research group focuses on quantification of the imaging, and developing tools which allow radiation therapy to be delivered in a safer and more validated manner.

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Selected Publications

• Mastanduno, M.A., Xu, J., El-Ghussein, F., Jiang, S., Yin, H., Zhao, Y., Wang, K., Ren, F., Gui, J., Pogue, B.W., and Paulsen, K.D., "MR-guided near-infrared spectral tomography increases diagnostic performance of breast MRI," Clin Cancer Res. May 27 (2015) [Epub ahead of print]
• Zhao, Y., Mastanduno, M.A., Jiang, S., Gui, J., Pogue, B.W., and Paulsen, K.D. "Optimization of image reconstruction for MRI guided near infrared diffuse optical spectroscopy in breast," Journal of Biomedical Optics, 20, 56009, (2015)
• Jiang S., Pogue B.W., Kaufman P.A., Gui J., Jermyn M., Frazee T.E., et al., "Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment," Clinical Cancer Research, 20(23), 6006-15 (2014)
• El-Ghussein, F., Jiang, S., Pogue, B.W., and Paulsen, K.D., "Comparison of magnetic resonance imaging-compatible optical detectors for in-magnet tissue spectroscopy: photodiodes versus silicon photomultipliers," Journal of Biomedical Optics 19, 070502 (2014)
• Jiang, S., Pogue, B.W., Jermyn, M.A., Frazee, T. E., Michaelsen, K., Paulsen, K.D., and Kaufman P.A., "Assessing breast tissue oxygenation by using inspired gas stimulation with NIR tomography," J. Biomedical Optics, 19(1) 130174SSR (2013)
• Li, Z., Jiang, S., Krishnaswamy, V., Davis, S.C., Srinivasan, S., Paulsen, K.D., and Pogue, B.W., "MR-guild pulse oximetry imaging of breast in vivo," J. Innovative Opt. Health Sci., 4(2), 199-208 (2011)
• Carpenter, C.M., Rakow-Penner, R., Jiang, S., Daniel, B.L., Pogue, B.W., Glover, G.H. and Paulsen, K.D., "Monitoring of Hemodynamic Changes Induced in the Healthy Breast through Inspired Gas Stimuli with MR guided Diffuse Optical Imaging," Medical Physics 37(4), 1638-1646 (2010)
• Jiang, S., Pogue, B.W., Carpenter, C.M., Poplack, S.P., Wells, W.A., Kogel, C.A., Forero, J., Muffly L.S., Schwartz, G.N., Paulsen, K.D. and Kaufman, P.A., "Evaluation of breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography: Case studies of tumor region of interest changes," Radiology, 252(2), 551-560. PMCID: PMC2753781 (2009)
• Jiang, S., Pogue, B.W., Laughney, A.M., Kogel, C.A. and Paulsen, K.D., "Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging," Appl. Opt. 48(10), D130–D136 (2009)
• Jiang, S., Pogue, B.W., Laughney, A.M., Kogel, C.A. and Paulsen, K.D., "Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging," Appl. Opt. 48(10), D130–D136 (2009)
• Wang, J., Jiang, S., Paulsen, K.D. and Pogue, B.W. "Broadband frequency-domain NIR spectral tomography using a mode locked Ti:Sapphire laser," Appl. Opt. 48(10), D198–D207 (2009)
• Jiang, S., Pogue, B.W., Carpenter, C.M., Poplack, S.P., Wells, W. A., Kogel, C.A., Forero, J., Muffly L.S., Schwartz, G.N., Paulsen, K.D. and Kaufman, P.A., "Evaluating tumor response to neoadjuvant chemotherapy with Diffuse Optical Spectroscopic Tomography: Case studies of tumor Region of Interest changes," Radiology, 252(2), 551-560 (2009)

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