Shudong Jiang

Research Interests

Optical spectroscopy and imaging systems for biomedical applications

Education

BS, Automatic control system, University of Xian Institute of Technology (China)
MS, Optoelectronics, Fukui University (Japan)
PhD, Optoelectronics, Tokyo Institute of Technology (Japan) 1992

Awards

Senior Member, Optical Society of America (OSA)

Research Projects

Optical molecular imaging

Optical molecular imaging

Optical molecular imaging is being used to provide molecular guidance in cancer surgery. Fluorescent contrast agents are in pre-clinical and clinical studies to image cancer tumors in vivo, with a dual focus, first on getting more accurate information out of the tissue, and secondly to provide better information about the specificity of the molecules as markers. Systems and algorithms for diffuse fluorescence imaging of tissue are studied, both as a stand-alone system, and as coupled to magnetic resonance imaging and computed tomography imaging. Tracer kinetic modeling is also being developed to allow quantitative imaging of molecular binding in vivo.
Near-infrared imaging

Near-infrared imaging

Near-infrared imaging (NIR) provides a way to quantify blood and water concentrations in tissue, as well as structural and functional parameters. Since normal tissue, benign tumors, and malignant tumors each carry different concentrations of both hemoglobin and water, and have different levels of oxygen demand and ultrastructural scattering, NIR spectroscopy can be combined into standard imaging systems as an effective method of to provide additional information for breast cancer detection and diagnosis. Work is ongoing to improve techniques for better image reconstruction, display and integration with magnetic resonance imaging (MRI) and computed tomography (CT) imaging.
See also Center for Imaging Medicine

Selected Publications

Tang Y, Yan S, Jiang S, Elliott J T, Cao X, Fisher L, Recendez C L, Henderson E R, and Gitajn I L. (2026) ICG-based fluorescence imaging to assess muscle perfusion for guiding surgical debridement after acute compartment syndrome, Injury (in press).
Zhao M, Cao X, Feng J, Zhou M, Wei C, diFlorio-Alexander R M, Pogue, B W, Jiang S, and Paulsen K D. (2025) MRI-guided near-infrared spectroscopic tomography (MRg-NIRST) imaging system with wearable breast optical interface for breast cancer imaging, IEEE Transactions on Biomedical Engineering 72, 899–908.
Feng J, Tang Y, Lin S, Jiang S, Xu J, Zhang W, Paulsen K D, et al. (2025). Deep learning enables fast and accurate quantification of MRI-guided near-infrared spectral tomography for breast cancer diagnosis. IEEE Transactions on Medical Imaging 44(11), 4390–4403. doi:10.1109/TMI.2025.3574727
Wei C, Li Z, Hu T, Zhao M, Sun Z, Jia K, Feng J, Pogue B W, Paulsen K D, and Jiang S. (2025) Model-based convolution neural network for 3D Near-infrared spectral tomography, IEEE Transactions on Medical Imaging 44(5), 2330–2340. PMCID: PMC12153047
Cao X, Muller K E, Chamberlin M D, Gui J, Kaufman P A, Schwartz G N, diFlorio-Alexander R M, Pogue B, Paulsen K D, and Jiang S. (2023). Near-infrared spectral tomography for predicting residual cancer burden during early stage neoadjuvant chemotherapy for breast cancer. Clin Cancer Res, 29(23),4822–4829. PMID: 37733788
Cao X, Rao Allu S, Jiang S, Jia M, Gunn JR, Yao C, LaRochelle E P, Shell J R, Bruza P, Gladstone D J, Jarvis L A, Tian J, Vinogradov S A, Pogue B W. (2020). Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy. Nat Commun 11(1):573. PMCID: PMC6989492
Gitajn I L, Slobogean G P, Henderson E R, von Keudell A G, Harris M B, Scolaro J A, O'Hara N N, Elliott J T, Pogue B W, Jiang S. (2020). Perspective on optical imaging for functional assessment in musculoskeletal extremity trauma surgery. J Biomed Opt 25(8). PMCID: PMC7457961
Gitajn I L, Elliott J T, Gunn J R, Ruiz A J, Henderson E R, Pogue B W, Jiang S. (2020). Evaluation of bone perfusion during open orthopedic surgery using quantitative dynamic contrast-enhanced fluorescence imaging. Biomed Opt Express 11(11):6458–6469. PMCID: PMC7687926
Cao X, Jiang S, Jia M, Gunn J, Miao T, Davis S C, Bruza P, Pogue B W. (2018). Observation of short wavelength infrared (SWIR) Cherenkov emission. Opt Lett 43(16):3854–3857. PMCID: PMC7577552
Feng J, Xu J, Jiang S, Yin H, Zhao Y, Gui J, Wang K, Lv X, Ren F, Pogue B W, Paulsen K D. (2017). Addition of T2-guided optical tomography improves noncontrast breast magnetic resonance imaging diagnosis. Breast Cancer Res 19(1):117. PMCID: PMC5655871
Zhao Y, Burger W R, Zhou M, Bernhardt E B, Kaufman P A, Patel R R, Angeles C V, Pogue B W, Paulsen K D, Jiang S. (2017). Collagen quantification in breast tissue using a 12-wavelength near infrared spectral tomography (NIRST) system. Biomed Opt Express 8(9):4217–4229. PMCID: PMC5611936
Jiang S, Pogue B W, Kaufman P A, Gui J, Jermyn M, Frazee T E, Poplack S P, DiFlorio-Alexander R, Wells W A, Paulsen K D. (2014). Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment. Clin Cancer Res 20(23):6006–6015. PMCID: PMC4254218

Patents

Medical imaging technique using x-ray to near-infrared downconverting nanopowder | 12337041
Method and apparatus to measure bone hemodynamics and discriminate healthy from diseased bone, and open reduction internal fixation implant with integrated optical sensors | 12257066
Pulsed lasers in frequency domain diffuse optical tomography and spectroscopy | 8634082
Systems and methods for tomographic image reconstruction | 8000775