Samuel S. Streeter

Overview

Samuel earned his PhD in biomedical optics from Thayer School of Engineering at Dartmouth with support from a Ruth L. Kirschstein Predoctoral Individual National Research Service Award fellowship. After graduating, he was an assistant professor at Geisel School of Medicine at Dartmouth and a scientist in the Department of Orthopaedics at Dartmouth Health, where he developed optical and near-infrared imaging technologies for surgical guidance and diagnostic applications. Samuel's research interests include quantitative optical imaging, fluorescence-guided surgery, multimodal approaches, and preclinical modeling of disease processes.

Research Interests

Biomedical optics; image-guided surgery; fluorescence imaging; cancer research

Education

• AB, Engineering Sciences, Dartmouth 2013
• BE, Engineering Sciences, Dartmouth 2014
• PhD, Engineering Sciences, Dartmouth 2022

Awards

• Ruth L. Kirschstein National Research Service Award (F31) Individual Fellowship, Dartmouth
• John W. Strohbehn, PhD, Memorial Prize, Dartmouth

Research Projects

• Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green Kinetic Modeling

  Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green Kinetic Modeling

  Necrotizing soft tissue infections (NSTIs) are aggressive infections that can progress rapidly from mild symptoms to sepsis, multi-organ failure, and death. NSTI cases present with non-specific clinical, imaging, and laboratory findings. Standard-of-care techniques for NSTI diagnosis lack sensitivity and specificity. A distinguishing histological feature of NSTIs is prominent blood vessel thrombosis in affected tissues. Leveraging this pro-thrombotic effect, our study group has demonstrated in a first-in-human study (NCT04839302) that intravenous administration of indocyanine green (ICG) and immediate fluorescence imaging reveals prominent signal deficits in NSTI-positive tissues. Our team is now leading a prospective, observational, multicenter clinical study to study video-rate ICG fluorescence imaging of patients suspected of having NSTIs who present to eight tertiary, Level 1 medical centers across the United States. The overall goal is to investigate whether ICG fluorescence imaging may act as a rapid diagnostic tool for NSTI, improving outcomes for patients with these life-threatening infections.

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Selected Publications

• Ray GS, Streeter SS, Bateman LM, Elliott JT, Henderson ER. (2024) "Real-time identification of life-threatening necrotizing soft-tissue infections using indocyanine green fluorescence imaging." Journal of Biomedical Optics. 29(6): 066003.
• Streeter SS, Zuurbier RA, diFlorio-Alexander RM, Hansberry MT, Maloney BW, Pogue BW, Wells WA, Paulsen KD, Barth RJ. (2023) "Breast-conserving surgery margin guidance using micro-computed tomography: Challenges when imaging radiodense resection specimens." Annals of Surgical Oncology. 30(7): 4097–4108.
• LaRochelle EPM, Streeter SS, Littler EA, Ruiz AJ. (2023) "3D-printed tumor phantoms for assessment of in vivo fluorescence imaging analysis methods." Molecular Imaging and Biology. 25(1): 212–220.
• Ruiz AJ, Garg S, Streeter SS, Giallorenzi MK, LaRochelle EPM, Samkoe KS, Pogue BW. (2021) "3D printing fluorescent material with tunable optical properties." Scientific Reports. 11(1): 17135.
• Streeter SS, Maloney BW, Zuurbier RA, Wells WA, Barth RJ, Paulsen KD, Pogue BW. (2021) "Optical scatter imaging of resected breast tumor structures matches the patterns of micro-computed tomography." Physics in Medicine & Biology. 66(11).
• Streeter SS, Hunt B, Zuurbier RA, Wells WA, Paulsen KD, Pogue BW. (2021) "Developing diagnostic assessment of breast lumpectomy tissues using radiomic and optical signatures." Scientific Reports. 11(1): 21832.
• Streeter SS, Maloney BW, Paulsen KD, Pogue BW. (2020) "Active line scan with spatial gating for sub-diffuse reflectance imaging of scatter microtexture." Optics Letters. 45(23): 6378–6381.