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Periannan Kuppusamy

Adjunct Professor of Engineering

Professor of Radiology
Professor of Medicine
Adjunct Professor of Chemistry

Overview

Dr. Kuppusamy received his PhD in 1985 from the Indian Institute of Technology, Chennai, India. Following a two-year NIH Fogarty Fellowship from NIH/NIA, he joined the faculty in the Department of Medicine at the Johns Hopkins University School of Medicine. He then moved to Ohio State University in 2002, where he held the William D. and Jacquelyn L. Wells Chair in Imaging Research. He also served as the associate director of the Division of Cardiovascular Medicine. He joined Geisel School of Medicine at Dartmouth in 2013. Kuppusamy's research interests include free radicals, oxygen and oxygen biology in cardiovascular diseases and cancer. He is well-known for his expertise in the development of imaging methods for imaging oxygen and free radicals in biological systems. Kuppusamy has received numerous research awards including a Silver Medal in 2006 from the International EPR Society for significant contribution to the development of EPR imaging for biomedical applications, and Doctor of Medicine (honoris causa) in 2008 from University of Pecs (Pecs, Hungary) for cardiovascular research. Kuppusamy has published over 400 peer-reviewed research manuscripts in leading biomedical journals. He has received several research grants from the American Heart Association and National Institutes of Health. He has several patents on the probes and methods for determination of oxygen concentration in tissues. One of his inventions, OxyChip, is in clinical trial.

Research Interests

Free radicals; oxygen; electron paramagnetic resonance; oximetry; multi-modal imaging; clinical oximetry; OxyChip; EPR instrumentation

Education

  • BSc, Chemistry, Physics, Math, University of Madras (1975)
  • MSc, Chemistry, University of Madras (1977)
  • PhD, Chemistry, Indian Institute of Technology, Chennai (1985)

Awards

  • Distinguished Alumni Award, Indian Institute of Technology (IIT), Chennai, 2015
  • Lumley Interdisciplinary Research Award by College of Engineering, Ohio State University, 2011
  • Honorary Doctorate (“Doctor Honoris Causa”) awarded by the University of Pecs, Pecs, Hungary for Medical Sciences, 2008
  • Silver Medal in Biology/Medicine award by International EPR Society in recognition of development of EPR imaging and in vivo EPR for biological applications, 2006
  • Research Investigator Award by American Tamil Medical Association (ATMA) for outstanding achievements in biomedical research, 2006
  • Distinguished Mentor Award by Davis Heart and Lung Research Institute for recognition of outstanding mentoring and teaching activities in the institute, 2006
  • William D. and Jacquelyn L. Wells Chair in Imaging Research, 2005-2013
  • Established Investigator Award, American Heart Association (National Center), 1996-2001

Selected Publications

  • Kmiec MM, Hebert KA, Tse D, Hodge S, Williams BB, Schaner PE, Kuppusamy P. OxyChip embedded with radio-opaque gold nanoparticles for anatomic registration and oximetry in tissues. Magn Reson Med 87(3):1621-1637 (2022).
  • Schaner PE, Williams BB, Chen EY, Pettus JR, Schreiber WA, Kmiec MM, Jarvis LA, Pastel DA, Zuurbier RA, DiFlorio-Alexander RM, Paydarfar JA, Gosselin BJ, Barth RJ, Rosenkranz KM, Petryakov SV, Hou H, Tse D, Pletnev A, Flood AB, Wood VA, Hebert KA, Mosher RE, Demidenko E, Swartz HM, and Kuppusamy P (2021) First-In-Human Study in Cancer Patients Establishing the Feasibility of Oxygen Measurements in Tumors Using Electron Paramagnetic Resonance with the OxyChip. Front Oncol. 11:743256. doi: 10.3389/fonc.2021.743256
  • Schaner P E, Pettus JR, Flood AB, Williams BB, Jarvis LA, Chen EY, Pastel DA, Zuurbier RA, diFlorio-Alexander RM, Swartz HM and Kuppusamy P. OxyChip Implantation and Subsequent Electron Paramagnetic Resonance Oximetry in Human Tumors Is Safe and Feasible: First Experience in 24 Patients. Front Oncol, 10: 572060 (2020). doi: 10.3389/fonc/2020.572060
  • Demidenko E, Kmiec MM, Kuppusamy P. Estimation of pO2 distribution in EPR oximetry. J Magn Reson, 328: 106992 (2021) DOI: 10.1016/j.jmr.2021.106992
  • 3Kuppusamy P, Kmiec, MM, Tse D, Mast JM, Ahmad, R. Estimation of pO2 histogram from a composite EPR Spectrum of multiple random implants. Biomed Microdev, 22(1):3 (2019) doi: 10.1007/s10544-019-0451-4. PMID: 31797058.
  • Kmiec MM, Dan T, Mast JM, Dan T, Ahmad R, Kuppusamy P. Implantable microchip containing oxygen-sensing paramagnetic crystals for long-term, repeated, and multisite in vivo oximetry. Biomedical Microdevices 21(3): 71–87 (2019).
  • Kmiec MM, Hou H, Kuppusamy ML, Drews TM, Prabhat AM, Petryakov SV, Demidenko E, Schaner PE, Buckey JC, Blank A, Kuppusamy P. Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film. Magn Reson Med 81:781-794 (2019)
  • Kmiec MM, Hou H, Kuppusamy ML, Drews TM, Prabhat AM, Petryakov SV, Demidenko E, Schaner PE, Buckey JC, Blank A, Kuppusamy P. Application of SPOT chip for transcutaneous oximetry. Magn Reson Med 81:2837–2840 (2019).
  • Prabhat AM, Kuppusamy ML, Naidu SK, Meduru S, Reddy PT, Dominic A, Khan M, Rivera BK, Kuppusamy P. Supplemental oxygen protects heart against acute myocardial infarction. Frontiers in Cardiovascular Medicine, 5, 114 (2018). PMCID: PMC6120988 DOI: 10.3389/fcvm.2018.00114
  • 370. Mast JM, Kuppusamy P. Hyperoxygenation as a therapeutic supplement for treatment of triple-negative breast cancer. Frontiers in Oncology 8, 527 (2018). https://doi.org/10.3389/fonc.2...
  • Hou H, Khan N, Gohain S, Kuppusamy ML, and Kuppusamy P. Pre-clinical evaluation of OxyChip for long-term EPR oximetry. Biomed Microdevices 20(2): 29 (2018).
  • Wolfson H, Ahmad R, Twig Y, Blank A, Kuppusamy P. A hand-held EPR scanner for transcutaneous oximetry. Proceedings Volume 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging; 941706 (2015).

Patents

  • Nanoparticulate probe for in vivo monitoring of tissue oxygenation | 8,568,694