Eric Henderson

Adjunct Associate Professor of Engineering

Associate Professor of Orthopaedic Surgery


Dr. Henderson is the Medical Director of the Sarcoma Oncology Program at the Dartmouth Cancer Center at DHMC. His clinical interests are in limb-sparing surgery for benign tumors and cancers of the bones and connective tissues, and metastatic bone disease. Henderson's research primarily involves improving the safety and efficacy of surgery for patients requiring complex limb salvage operations for cancer. In 2011, Henderson first-authored the world's largest-to-date series of limb-sparing surgeries for cancer, resulting in a failure classification system that has since been adopted by the International Society of Limb Salvage. Henderson collaborates with faculty at Thayer School of Engineering to improve surgical techniques through advanced optical navigation, particularly with fluorescence (this work is currently funded by NIH). Henderson has published over 100 scientific manuscripts and holds 15 medical device patents.

Research Interests

Osteosarcoma; Ewing sarcoma; limb salvage; limb-sparing surgery; endoprosthesis; arthroplasty; fluorescence


  • BA, English Literature (major) and Physics (minor), University of Florida 1998
  • MD, University of South Florida 2004
  • Residency, Orthopaedic Surgery 2011
  • Fellowship, Musculoskeletal Oncology 2012
  • Invited Fellowship, Istituti Ortopedici Rizzoli 2012


  • Best of AAOS (paper presentation)
  • Best of AAOS (paper presentation)
  • Mario Mercuri Award (Best Paper)
  • Governor’s Choice, Florida Trend Trendsetter

Professional Activities

  • Musculoskeletal Tumor Society - Musculoskeletal Tumor Registry Steering Committee (member); Musculoskeletal Tumor Registry Data Subcommittee (chair); Evidenced-Based Medicine Committee (member); Annual Meeting Committee (member)
  • Musculoskeletal Tumor Registry - co-PI and founding investigator
  • International Society of Limb Salvage (member)

Selected Publications

  • Sardar HS, Zai Q, Xu X, Gunn JR, Pogue BW, Paulsen KD, Henderson ER, Samkoe KS. Dual‐agent fluorescent labeling of soft‐tissue sarcomas improves the contrast based upon targeting both interstitial and cellular components of the tumor milieu. J Surgical Oncology,2020. PMID: 32885452
  • Henderson ER, Keeney BJ, Husson EG, Bernthal NM, Ji T, Pala E, Funovics PT, Groundland JS, Lozano-Calderon S, Puchner S, Zoller SD, Ruggieri P, Windhager R, Guo W, Hornicek FJ, Letson GD, MD, Temple HT. Non-Mechanical Revision Indications Portend Repeat Limb-Salvage Failure Following Total Femoral Replacement. J Bone Joint Surg, 2020
  • Xu X, Samkoe KS, Anderson M, Henderson ER. “Quantification of osteosarcoma mineralization on plain radiographs: novel software applications to assess response to chemotherapy” Proc. SPIE Int Soc Opt Eng. Vol 11223. PMCID: PMC7263182
  • Xu X, Samkoe KS, Henderson ER. "Effect of preoperative cancer treatment on epidermal growth factor receptor (EGFR) receptor expression level in ABY-029 guided sarcoma surgery," Proc. SPIE Int Soc Opt Eng. Vol 11222. PMCID: PMC7263172
  • Samkoe KS, Shahzad Sardar H, Gunn J, Feldwisch J, Linos K, Henderson ER, Pogue B, Paulsen K. Measuring microdose ABY-029 fluorescence signal in a primary human soft-tissue sarcoma resection. Proc SPIE Int Soc Opt Eng, 2019 PMC6783124
  • Samkoe KS, Bates BD, Hoffer-Hawlik KA, Sardar HS, Feldwisch J, Gunn JR, Paulsen KD, Pogue BW, Henderson ER. Pre-clinical imaging of epidermal growth factor receptor with ABY-029 in soft-tissue sarcoma for fluorescence-guided surgery and tumor detection. Journal of Surgical Oncology, 119(8) 2019 PMID 30950072
  • Samkoe KS, Bates BD, Elliott JT, LaRochelle E, Gunn JR, Marra K, Ramkumar DB, Bauer DF, Paulsen KD, Pogue BW, Henderson ER. Application of Fluorescence-Guided Surgery to Subsurface Cancers Requiring Wide Local Excision: Literature Review and Novel Developments Toward Indirect Visualization. Cancer Control, 25(1):2018 PMID: 29334971
  • Samkoe KS, Bates BD, Elliott JT, LaRochelle E, Gunn JR, Marra K, Ramkumar DB, Bauer DF, Paulsen KD, Pogue BW, Henderson ER. Development and evaluation of a connective tissue phantom model for subsurface visualization of cancers requiring wide local excision. Journal of Biomedical Optics, 22(12):2017 PMID: 29274143
  • Henderson ER, Keeney BK, Pala E, Funovics PT, Eward WC, Groundland JS, Ehrlichman LK, Puchner ST, Brigman BE, Ready JE, Temple HT, Ruggieri P, Windhager R, Letson GD, Hornicek FJ. The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique. Bone & Joint Journal, 99-B(4):2017 PMID: 28385944
  • Henderson ER, O’Connor ME, Ruggieri P, Windhager R, Funovics P, Gibbons CL, Guo W, Hornicek FJ, Temple HT, Letson GD. Classification of Failure of Limb Salvage after Surgery for Bone Tumours. The Bone & Joint Journal. 96(11);2014 PMID:
  • Henderson ER, Pepper AM, Binitie OT, Marulanda GA, Cheong D, Letson GD. Outcome of Lower-Limb Preservation with an Expandable Endoprosthesis After Bone Tumor Resection in Children. The Journal of Bone and Joint Surgery, 94(6);2012 PMID: 22438003
  • Henderson ER, Groundland J, Pala E, Dennis J, Wooten R, Cheong D, Mercuri M, Kotz R, Windhager R, Funovics P, Hornicek FJ, Temple HT, Ruggieri P, Letson GD. Failure Mode Classification of Tumor Endoprostheses: Retrospective Review of Five Institutions and a Literature Review. The Journal of Bone and Joint Surgery, 93(5);2011 PMID: 21368074