Home » People » Faculty » Tillman U. Gerngross

Tillman U. Gerngross

Education

• B.S./M.S., Chemical Engineering, Technical University of Vienna, Austria 1989
• Ph.D., Molecular Biology, Technical University of Vienna, Austria 1991

Research Interests

Protein engineering; glycoprotein engineering; high cell density fermentation technology; metabolic engineering; protein expression

Current Research Projects

• Cell-based protein purification systems
• Cellular engineering of protein expression hosts
• Fermentation processes
• Glyco-engineering of proteins
• Humanization of glycosylation in yeast
• Novel protein expression systems
• Resource and environmental analysis

Teaching

• ENGS 35: Biotechnology and Biochemical Engineering
• ENGS 160: Biotechnology and Biochemical Engineering
• ENGM 189: Topics in Engineering Management

Selected Publications

• Gerngross, T.U. It's the problem, stupid! Nature Biotechnology, 30, 742–744 (2012) (Full Text Version)
• Hamilton, S.R., R.C. Davidson, N. Sethuraman, J.H. Nett, Y. Jiang, S. Rios, P. Bobrowicz, T.A. Stadheim, H. Li, B-K. Choi, D. Hopkins, H. Wischnewski, J. Roser, T. Mitchell, R.R. Strawbridge, J. Hoopes, S. Wildt, T.U. Gerngross. Humanization of Yeast to Produce Complex Terminally Sialylated Glycoproteins. Science, 313(5792):1441-1443 (2006) (Abstract, Full Text Version)
• Li, H., N. Sethuraman, T.A. Stadheim, D. Zha, B. Prinz, N. Ballew, P. Bobrowicz, B-K. Choi, W.J. Cook, M. Cukan, N.R. Houston-Cummings, R. Davidson, B. Gong, S.R. Hamilton, J.P. Hoopes, Y. Jiang, N. Kim, R. Mansfield, J.H. Nett, S. Rios, R.l. Strawbridge, S. Wildt, T.U. Gerngross. Optimization of humanized IgGs in glycoengineered Pichia pastoris. Nature Biotechnology. 24, 210 - 215 (2006)
• Hamilton, S.R., H. Li, H. Wischnewski, A. Prasad, J.S. Kerley-Hamilton, T. Mitchell, A.J. Walling, R.C. Davidson, S. Wildt, and T.U. Gerngross. Intact {alpha}-1,2-endomannosidase is a typical type II membrane protein. Glycobiology. 15(6):615-24 (2005)
• Wildt, S., and T.U. Gerngross. The humanization of N-glycosylation pathways in yeast. Nature Reviews Microbiol. 3(2):119-28 (2005)
• Gerngross, T.U., Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nature-Biotechnology, 1409 -1414 (2004)
• Hamilton, S.R., P. Bobrowicz, B. Bobrowicz, H. Li, T. Mitchell, J.H. Nett, S. Rausch, T.A. Stadheim, S. Wildt, H. Wischnewski, and T.U. Gerngross. Production of complex human glycoproteins in yeast. Science, 301, 1244 (2003) (Abstract, Full Text Version)

Entrepreneurship

• Co-founder and scientific advisory board chair, GlycoFi
• Co-founder and CEO, Adimab
• Co-founder and President, Arsanis

News

• Two to Lead Office of Entrepreneurship & Technology Transfer
  Dartmouth Now
  April 11, 2013

• Location, Location Not an Obstacle to Biotech Success
  BioWorld Today
  January 16, 2013

• Getting By, Getting Ahead: Start-Up Entrepreneur Brings High-Tech Talent To Rural N.H.
  New Hampshire Public Radio
  July 10, 2012

• Biotechs strike partnerships to spread their costs, risks
  The Boston Globe
  January 15, 2012

• Biotech Vet Gerngross Dishes Out More Details On Latest VC-Backed Startup Arsanis
  Xconomy
  February 15, 2011

• New Gerngross startup Arsanis raises $9.6M
  Mass High Tech
  February 8, 2011

• NCI Awards $12.8 Million to Dartmouth Center of Cancer Nanotechnology Excellence
  Dartmouth Now
  September 17, 2010

• Meet the Tech Pioneers of 2011
  Business Week
  September 2, 2010

• What It Takes To Be A Biotech Entrepreneur
  Life Science Leader
  July 10, 2010

• The Promise And Pitfalls of Bioplastic
  TIME / CNN
  May 3, 2010

• Google, pharmaceutical giants pursue smarter antibody drug discovery
  SmartPlanet.com
  February 5, 2010

• Adimab grabs Series D funds, led by Google Ventures
  Mass High Tech
  October 1, 2009

• Google’s Venture Arm Invests in Biotech Start-Up
  The New York Times
  October 1, 2009

• Prof. creates biotechnical company
  The Dartmouth
  August 14, 2009

• Adimab believes its yeast-based antibody discovery system could change how biotherapeutics are found
  Chemical & Engineering News
  July 27, 2009

• Notes from BIO: Adimab Pulls Back the Curtain
  The IN VIVO Blog
  May 19, 2009

• Adimab’s antibody discoveries attract more funding
  Mass High Tech
  November 20, 2008

• Engineering profs chosen as NH “Entrepreneurs of the Year”
  Dartmouth News
  June 1, 2007

• Have Some Sugar with Your Protein
  Scientific American
  September 7, 2006

• Merck & Co., Inc. to Acquire GlycoFi, Inc.
  Merck
  September 5, 2006

• Glycosylation Engineering; Controlling Personalities Tame Wild Sugars on Proteins
  Chemical & Engineering News
  September 4, 2006

• Dartmouth and GlycoFi Report Full Humanization of Therapeutic Proteins from Yeast
  Dartmouth News
  August 9, 2006

• Merck to buy N.H. biotech in record bid
  The Boston Globe
  May 10, 2006

• In Who’s who in biotech
  Nature Biotechnology
  March 2, 2006

• Yeast Builds Better Monoclonal Antibodies
  Scientific American
  January 23, 2006

• Carbohydrate Advances
  Chemical & Engineering News, 83(32)
  August 8, 2005

• The 2004 Scientific American 50 Award: Business Leaders recognizes GlycoFi
  Scientific American
  November 11, 2004

• Supercharging Protein Manufacture
  Scientific American
  January 14, 2004

• Bioengineering
  Chemical and Engineering News
  December 22, 2003

• Hefepilze sollen empfindliche Hamsterzellen ersetzen
  Die Welt
  September 1, 2003

• Researchers tweak yeast DNA to produce human protein
  The Guardian, London
  August 29, 2003

• Yeast Engineered to Produce Sugared Human Proteins
  Science
  August 29, 2003

• Humanised yeast produce healing proteins
  Nature
  August 29, 2003

• Modified yeast produces fully human proteins
  New Scientist
  August 29, 2003

• Dartmouth Bioengineers Develop Humanized Yeast
  Science Daily
  August 29, 2003

• Yeast turned into drugs factory
  BBC News
  August 29, 2003

• Dartmouth Bioengineers Develop Humanized Yeast
  Dartmouth News
  August 28, 2003

• Sugar Added: Cheaper, better protein drugs through sweetening
  Scientific American
  July 15, 2003

• Dartmouth Engineers Closer To Mass-producing Therapeutic Proteins
  Science Daily
  April 18, 2003

• Dartmouth engineers closer to mass-producing therapeutic proteins
  Dartmouth News
  April 17, 2003

• Dartmouth researchers put recycling in perspective
  Dartmouth News
  March 7, 2003

• Biopolymers and the Environment
  Science
  February 7, 2003

• Dartmouth Engineering Professors Secure $7 Million
  May 20, 2002

• Analysis: Experts disagree over color of biomass
  Nature Biotechnology
  May 1, 2000

• Car Parts from Chickens
  Scientific American
  April 1, 2000

• Is ‘Green Manufacturing’ an oxymoron?
  Science a GoGo
  September 2, 1999

• Plastic from plants called costly
  CNN.com
  August 27, 1999

• Making Plastics from Plants May Waste Energy
  About.com
  August 1, 1999

In Dartmouth Engineer Magazine

• Kudos
  Winter 2013
• Kudos
  Summer 2011
• Kudos
  Summer 2010
• The Innovator: Biotech entrepreneur Tillman Gerngross reveals how he turns the impossible into multi-million-dollar companies
  Winter 2010
• Kudos
  Summer 2009
• Kudos
  Spring/Summer 2007
• Innovations: GlycoFi Bought by Merck
  Fall 2006
• Lab Reports: Antibodies from Yeast
  Spring 2006
• Kudos
  Spring 2005

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