David J. Gladstone

Research Interests

Ultra conformal radiation therapy; image guided radiation therapy; biological gating of therapeutic X-ray beams; image guided brachytherapy; cherenkov emission during radiotherapy; EPR dosimetry

Education

BSCh, University of Denver 1983
ScD, Massachusetts Institute of Technology 1989

Professional Activities

EPR Center, Geisel School of Medicine

Research Projects

Scintillation dosimetry for quality assurance in radiotherapy

Scintillation dosimetry for quality assurance in radiotherapy

Radiation therapy is used to treat cancer tumors by killing the tissue with high ionizing radiation doses. Modern external beam radiotherapy systems deliver high dose levels to precisely marked tumor volume in less time. As a mis-administration can have potentially severe impact to the surrounding healthy tissue, more stringent and complex quality assurance measurements are required in clinics. By developing a comprehensive optical dose imaging camera system, we aim to fundamentally simplify the quality assurance process and, in turn, to further promote the culture of safety in radiotherapy. By converting the dose to visible light using scintillation phantom, we can image and reconstruct 3D dose maps in real time, enabling complete and accurate verification in a fast enough timeframe for it to be useful in every procedure.

Selected Publications

Andreozzi JM, Zhang R, Glaser AK, Jarvis LA, Pogue BW, Gladstone DJ. "Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging." Med Phys 2015 Feb; 42(2):994-1004, PMID: 25652512
Zhang R, Andreozzi JM, Gladstone DJ, Hitchcock WL, Glaser AK, Jiang S, Pogue BW, Jarvis LA. "Cherenkoscopy based patient positioning validation and movement tracking during post-lumpectomy whole breast radiation therapy." Phys Med Biol 2015 Jan 7; 60(1):L1-14, PMID: 25504315
Holt RW, Zhang R, Esipova TV, Vinogradov SA, Glaser AK, Gladstone DJ, Pogue BW. "Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies." Phys Med Biol 2014 Sep 21; 59(18):5317-28, PMID: 25146556
Glaser AK, Zhang R, Gladstone DJ, Pogue BW. "Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose." Phys Med Biol 2014 Jul 21; 59(14):3789-811, PMID: 24938928
Glaser AK, Andreozzi JM, Davis SC, Zhang R, Pogue BW, Fox CJ, Gladstone DJ. "Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation." Med Phys 2014 Jun; 41(6):062102, PMID: 24877829
Jarvis LA, Zhang R, Gladstone DJ, Jiang S, Hitchcock W, Friedman OD, Glaser AK, Jermyn M, Pogue BW. "Cherenkov video imaging allows for the first visualization of radiation therapy in real time." Int J Radiat Oncol Biol Phys 2014 Jul 1; 89(3):615-22, PMID: 24685442
Zhang R, Gladstone DJ, Jarvis LA, Strawbridge RR, Jack Hoopes P, Friedman OD, Glaser AK, Pogue BW. "Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy." J Biomed Opt 2013 Nov; 18(11):110504, PMID: 24247743
Zhang R, Glaser AK, Gladstone DJ, Fox CJ, Pogue BW. "Superficial dosimetry imaging based on CÌŒerenkov emission for external beam radiotherapy with megavoltage x-ray beam." Med Phys 2013 Oct; 40(10):101914, PMID: 24089916
Zhang R, Fox CJ, Glaser AK, Gladstone DJ, Pogue BW. "Superficial dosimetry imaging of ÄŒerenkov emission in electron beam radiotherapy of phantoms." Phys Med Biol 2013 Aug 21; 58(16):5477-93, PMID: 23880473
Zhang R, Davis SC, Demers JL, Glaser AK, Gladstone DJ, Esipova TV, Vinogradov SA, Pogue BW. "Oxygen tomography by ÄŒerenkov-excited phosphorescence during external beam irradiation." J Biomed Opt 2013 May; 18(5):50503, PMID: 23644902

Patents

Dosimetry systems for radiation treatment using radiation-detector-triggered cameras to image cherenkov emissions or thin-sheet scintillators | 11,633,627