Jones Seminar: Utility of Breath Analysis to Diagnose and Monitor Systemic Disease

Raed Dweik, Professor of Medicine & Director, Pulmonary Vascular Program, Cleveland Clinic

Friday, May 29, 2015, 3:30–4:30pm

Spanos Auditorium, Cummings Hall

This seminar is part of the Jones Seminars on Science, Technology, and Society series.

As the headspace of the blood, our exhaled breath contains a vast array of substances and molecules that hold great promise for monitoring our health and for the diagnosis and management of various lung and systemic diseases. This includes substances we produce endogenously as part of our normal (or disease-related) metabolism whether this is local in the lung or systemic in origin. Since we are constantly inhaling air from our environment as we breathe in the ambient air, exhaled breath can also reflect our environmental exposure(s). Furthermore, our breath contains volatile compounds produced by our “internal environment”: the bacteria in our gut and mouth. Add to all of those volatile byproducts generated from our diet, medications, drugs, or toxins that we are exposed to and you get a very rich matrix that has great potential to revolutionize and personalize medicine. We are able to identify unique “breath-prints” in patients with liver disease (fetor hepaticus) as well as heart, kidney and other systemic diseases. We are further able to analyze these patterns to identify single molecules in the breath of these patients and link them to the underlying pathobiology of the disease.

About the Speaker

Raed A. Dweik, M.D. is the Director of the Pulmonary Vascular Program and the Breath Analysis Program at Cleveland Clinic. He is board certified in internal medicine, pulmonary disease, and critical care medicine. Dr. Dweik's clinical interests are in pulmonary hypertension and asthma. He has a joint appointment in the department of Pathobiology in the Lerner Research Institute (LRI) and is a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

Dr. Dweik's research interests are in exhaled breath analysis and the role of nitric oxide (NO) in cardiopulmonary physiology and disease especially pulmonary hypertension and asthma. He has been conducting translational research in NO biology for the last 18 years. More recently, Dr. Dweik chaired the committee that published the official American Thoracic Society clinical practice guidelines for the interpretation of exhaled nitric oxide levels (FENO) for clinical applications.

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