Special Seminar: Translational Photoacoustic Imaging of Micrometastases in the Lymphatics

Geoffrey Luke, Research Scientist, University of Texas at Austin and MD Anderson Cancer Center

Wednesday, March 25, 2015, 4:00–5:00pm

Spanos Auditorium, Cummings Hall

Abstract

Photoacoustic imaging is a hybrid biomedical imaging technology which combines the high contrast and molecular specificity of optical imaging with the excellent resolution of ultrasound imaging. Despite the fact that it has demonstrated great potential in the preclinical realm, photoacoustic imaging has yet to make an impact in the clinic. In this talk, I will discuss our strategy and recent advances to translate photoacoustic imaging for the detection of lymph node micrometastases in breast cancer patients. By applying spectroscopic techniques, we are able to observe changes in blood oxygen saturation in murine lymph nodes resulting from metastasis without the need for exogenous contrast agents or ionizing radiation. I will also present our long-term strategy to employ molecularly activated nanoparticle contrast agents for enhanced sensitivity and specificity.

About the Speaker

Geoffrey Luke earned his B.S. in computer engineering and mathematics and M.S. in eectrical engineering from the University of Wyoming. He then graduated from the University of Texas at Austin with a Ph.D. in electrical engineering. He is currently a research scientist with a joint appointment at the University of Texas at Austin and MD Anderson Cancer Center. His research is focused on creating translatable technologies that combine light, sound, and nanotechnology for the detection, characterization, and treatment monitoring of cancer.

For more information, contact Haley Tucker at haley.tucker@dartmouth.edu.