Positron Emission Tomography (PET) Imaging in Neuroscience and Diabetes

Richard E. Carson, Professor of Diagnostic Radiology and of Biomedical Engineering; Director, Yale PET Center; Director of Graduate Studies, Biomedical Engineering, Yale University

Friday, October 24, 2014, 3:30pm

Spanos Auditorium

This seminar is part of the Jones Seminars on Science, Technology, and Society series.

Positron Emission Tomography (PET) is a noninvasive imaging technology that uses radiopharmaceuticals to trace in vivo physiology and pharmacology. With the application of mathematical models to dynamic tracer data, parametric images of blood flow, metabolism, receptor availability and target occupancy can be obtained. These are applied in preclinical and clinical studies to evaluate mechanisms of disease and drug-receptor interactions. This presentation will give an introduction to quantitative PET methodology with specific application in neuroscience and neuropsychiatric disorders. In addition, novel methodology to assess pancreatic beta-cell mass with PET will be presented.

About the Speaker

Richard E. Carson received his Ph.D. from UCLA in 1983 in Biomathematics. From that time on, he has focused his research on the development and application of mathematical techniques for the study of human beings and non-human primates with Positron Emission Tomography (PET), a noninvasive imaging technology that uses radiopharmaceuticals to trace in vivo physiology and pharmacology. From 1983 until 2005, Dr. Carson was an integral part of the PET program at the National Institutes of Health, rising to the rank of Senior Scientist. In 2005, Dr. Carson joined the faculty of Yale University as Professor of Biomedical Engineering and Diagnostic Radiology. He is Director of the Yale PET Center, a state-of-the-art facility focused on quantitative PET techniques using novel radiopharmaceuticals. Dr. Carson is also Director of Graduate Studies in Biomedical Engineering at Yale.

Dr. Carson's research interests are concentrated in the following areas:

  1. New algorithms for image reconstruction with PET.
  2. Development of mathematical models for novel radiopharmaceuticals to produce images of physiological parameters.
  3. Use of receptor-binding ligands to measure drug occupancy and dynamic changes in neurotransmitters by analysis of PET tracer signals.
  4. Applications of PET tracers in clinical populations and preclinical models of disease, including neuropsychiatric disorders, diabetes, and cancer.

Dr. Carson has published over 200 papers in peer-reviewed journals, given over 100 invited lectures, and is a member of the editorial board of two of the leading journals in the field of PET imaging, the Journal of Nuclear Medicine, and the Journal of Cerebral Blood Flow and Metabolism. Dr. Carson was awarded the Kuhl-Lassen award from the Brain Imaging Council of the Society of Nuclear Medicine in 2007. He became a member of the College of Fellows of the American Institute for Medical and Biological Engineering in 2008 and was awarded the Sheffield Distinguished Teaching Award from the Yale School of Engineering. In 2009, he was named the winner of the Ed Hoffman Memorial Award from the Computer and Instrumentation Council of the Society of Nuclear Medicine and was named as one of the 25 most influential in the field of Radiology by RT-Image. In 2010, Dr. Carson was named as a member of the Connecticut Academy of Science and Engineering.

For more information, contact Haley Tucker at haley.tucker@dartmouth.edu.