Mechanoadaptation of Bone in Growth, Maintenance and Disease

Sandra Shefelbine, Assistant Professor, Imperial College, London

Monday, January 24, 2011, 3:30pm

This seminar is part of the Jones Seminars on Science, Technology, and Society series

The primary role of long bones is to support load. It is therefore not surprising that bones adapt to mechanical loads. This seminar will present on-going work in Dr. Shefelbine's lab that examines (1) the influence of loading on bone morphology during growth, in particular bone deformities in cerebral palsy, (2) adaptation of bone to mechanical loads, explored through use of animal models of imposed loading, and (3) mechanical causes of bone pathology, such as osteoarthritis and brittle bone disease. These projects aim to link the mechanical environment with the biological response in order to understand the adaptive mechanisms of bone.

About the Speaker

Dr. Sandra J. Shefelbine, is currently a faculty member in the Department of Bioengineering at Imperial College London. She received her BSE from Princeton University (1997) in Mechanical and Aerospace Engineering, an MPhil in Engineering Design from Cambridge University (1998), and a PhD from Stanford University (2002) in Mechanical Engineering. She was recipient of the National Science Foundation International Post-Doctoral Fellowship and worked at the Institute for Orthopedic Research (Ulm, Germany). Her research uses computational methods, animal experiments, and clinical collaborations to determine the influence of mechanical loads on bones.