Special Seminar: Imaging cancer metabolism using hyperpolarized 13C MR spectroscopy and quantitative susceptibility mapping

Jae Mo Park, Postdoctoral Research Fellow, Dept of Radiology, Stanford University

Wednesday, March 18, 2015, 4:00–5:00pm

Room 200, Cummings Hall

Abstract

In parallel to the explosive growth of molecular imaging methods to assess in vivo gene expression, there has been a renewed interest in imaging metabolism, with positron emission tomography (PET) being the dominant modality. In this talk, I will discuss studies directed toward advancing the metabolic imaging for cancer using two MR techniques: hyperpolarized 13C MR spectroscopy (MRS) and quatitative susceptibility mapping (QSM). The advent of hyperpolarized MRS provides tremendous new opportunities to noninvasively image both the injected substrate and downstream metabolic products, thereby providing unprecedented in vivo assessments of flux and label exchange through critical pathways. Difference in tissue magnetic susceptibility is another source of MR contrasts, providing additional cellular information such as tissue iron contents and oxygenation. First, I will present the imaging methods using hyperpolarized 13C MRS to assess glucose utilization in cancer. Second, I will discuss the accelerated imaging acquisition of tissue magnetic susceptibility with application of pediatric brain tumor patients.

About the Speaker

Jae Mo Park received his B.S. from Yonsei University, South Korea in 2005 and M.S. and Ph.D. from Stanford University in 2009 and 2012, respectively, all in electrical engineering. Since 2012, he has been a postdoctoral research fellow in the Department of Radiology at Stanford University. His research interest lies in 1) the development of novel noninvasive molecular imaging tools using MRI/MRS to elucidate in vivo metabolism and function of normal and pathological states, 2) the identification of characteristics in metabolic diseases, and 3) the application to translational and clinical investigation. 

For more information, contact Haley Tucker at haley.tucker@dartmouth.edu.