CEO, Upstream Bio, Cambridge, MA
Board Chair: Elected 2015
Chair of the Board 2020–present
BE Thayer School of Engineering
MBA Tuck School of Business
Samantha Truex is CEO of Upstream Bio. Sam has served in leadership roles at multiple venture-backed companies including as CEO of Quench Bio, COO of Synlogic and CBO for Padlock Therapeutics. Previously, Sam was vice president of corporate development at Biogen where she led transactional business development activities and served as program executive for now-marketed products FAMPYRA®, ELOCTATE™ and ALPROLIX™. Sam also previously worked in corporate development at Genzyme, Chiron Diagnostics and Health Advances. Sam earned an AB in biology from Dartmouth, a BE in biomedical engineering from Thayer and an MBA from Tuck. Sam is also on the boards of Thayer, Hotspot Therapeutics, and Life Science Cares. Sam has previously served terms on Dartmouth's Alumni Council and Thayer's Corporate Collaboration Council.