- Research
Research Areas
Research Activity
B. Stuart Trembly
Associate Professor of Engineering
Professor Trembly developed a microwave thermokeratoplasty technique to correct nearsightedness is now working to thermally treat lung cancer using minimally-invasive ablation techniques. (Photo by Chris Milliman)
Education
- BS, Engineering and Applied Science, Yale University 1975
- PhD, Engineering Sciences, Dartmouth 1983
Research Interests
Therapeutic heating of tissue; dielectric properties of tissue; biomedical engineering; antenna theory
Selected Publications
- Barton, M.D. and B.S. Trembly, “Measurement of the Anisotropic Thermal Conductivity of the Cornea,” Experimental Eye Research 115(October):216-223, 2013.
- Zulauf, G.D., B.S. Trembly, A.J. Giustini, B.R. Flint, R.R. Strawbridge, and P.J. Hoopes, “Targeting of systemically-delivered magnetic nanoparticle hyperthermia using a noninvasive, static, external magnetic field,” Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840C, 2013.
- Petryk, A.A., A.J. Giustini, R.E. Gottesman, B.S. Trembly, and P.J. Hoopes, “Comparison of magnetic nanoparticle and microwave hyperthermia cancer treatment methodology and treatment effect in a rodent breast cancer model,” Int J Hyperthermia 29(8):819–827, 2013.
- Nieskowski, M.D. and B.S. Trembly, “Comparison of a Single Optimized Coil and a Helmholtz Pair for Magnetic Nanoparticle Hyperthermia,” IEEE Transactions on Biomedical Engineering 61(6):1642-1650, 2014.
Awards
- Senior Member, National Academy of Inventors, elected 2020
- Dartmouth Technology Innovation and Commercialization Award, 2019
- National Science Foundation, Presidential Young Investigators Award, 1984
Patents
- Systems and methods for enhancing uptake of therapeutic agent from bloodstream into disease site | 10,485,481
- Method and apparatus utilizing magnetic nanoparticles for sterilizing female placental mammals, including women | 9,271,789
- Thermal treatment apparatus | 8,521,302
- Thermal treatment system with acoustic monitoring, and associated methods | 8,348,936
- Feedback control of thermokeratoplasty treatments | 7,377,917
- Apparatus and method for the treatment of infectious disease in keratinized tissue | 7,292,893
- Thermokeratoplasty systems | 7,192,429
- System and methods for fallopian tube occlusion | 6,485,486
- Tissue sealing using microwaves | 6,224,593
- Microwave applicator for transurethral hyperthermia | 5,301,687
- Combined microwave heating and surface cooling of the cornea | 4,881,543
Startups
Research Projects
-
Therapeutic heating of tissue
Therapeutic heating of tissue
Selectively elevating the temperature of body tissue has a variety of therapeutic effects. Different methods of microwave heating are being developed for use in cornea reshaping, fallopian tube occlusion, and treatment of benign prostatic hyperplasia as well as liver and prostate cancer.
-
Dielectric properties of tissue
Dielectric properties of tissue
Dielectric properties of tissue—measured through advanced microwave imaging techniques—convey functional information useful for making clinical diagnoses. The properties reflect tissue composition of fat, bone, water, proteins, etc., and often have unique spectral characteristics. The relative proportions and dynamic aspects of these constituents can have important implications for breast cancer imaging, osteoporosis detection, brain imaging, and heat therapy monitoring.
News
