Regina S. Salvat — Clare Boothe Luce Graduate Fellowship

Faculty Advisor: Karl Griswold

Dr. Regina Salvat’s research examined experimental validation of deimmunization algorithms using the Enterobacter cloacae P99 β-lactamase, a component of Antibody Directed Enzyme Prodrug Therapies, as a model protein. Biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy. Regina's work provides a rich data set for assessing the accuracy, efficiency, and overall utility of cutting-edge biotherapeutic deimmunization technologies. Her methods aim to accelerate the biotherapeutic design and development process. [Read more.]

Videos

• Cancer Therapy Research at Dartmouth
• PhD Innovation Program - Regina Salvat

Selected Articles

• Highlight of “Structure-based Design Algorithms for Biotherapeutic Deimmunization”, Immuno-oncology News (2015)
• Spotlight feature of “Structure-based Design Algorithms for Biotherapeutic Deimmunization”, Biotechnology and Bioengineering (2015)
• Highlight of systematic analysis of biotherapeutic deimmunization, Medical Press (2015)

Publications

• Structure-based Redesign of Lysostaphin Yields Potent Anti-Staphylococcal Enzymes that Evade Immune Cell Surveillance, Molecular Therapy (2015
• Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads, Biotechnology & Bioengineering (2015)
• Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate, PLoS Computational Biology (2015)
• Computationally Driven Deletion of Broadly Distributed T cell Epitopes in a Biotherapeutic Candidate, Cellular and Molecular Life Sciences (2014)
• A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes, Journal of Visualized Experiments (2014)

Geneva Trotter — Clare Boothe Luce Graduate Fellowship

Faculty Advisor: Ian Baker

Geneva Trotter's PhD research at Dartmouth involves studying both the effects of deformation (rolling) on the precipitation processes in Lave phase-strengthened austenitic steels, including determining the mechanism of NiAl co-precipitation, and how these two kinds of precipitates affect subsequent deformation processes. A better understanding of the fundamentals and underlying causes of mechanical and microstructural responses observed in this alloy can be used as a model for other systems with complex matrix-precipitate relationships.

Videos

• Engineering New Alloys for Energy - Geneva Trotter
• PhD Innovation Program - Geneva Trotter

Selected Presentations

• Integrated Computational Materials Engineering for advanced high-strength cast iron, TMS Annual Meeting & Exhibition (2015)
• Analysis of the Role of Cold Work and Aging in the Precipitation of Laves Phase in an Alumina-Forming Austenitic Stainless Steel, MRS Fall Meeting (2014)

Publications

• The Effects of Cold Work on the Microstructure and Mechanical Properties of Intermetallic Strengthened Alumina-Forming Austenitic Stainless Steels, Metallurgical and Materials Transactions A (2015)
• The effect of aging on the microstructure and mechanical behavior of the alumina-forming austenitic stainless steel Fe–20Cr–30Ni–2Nb–5Al, Materials Science and Engineering: A (2014)
• Accelerated precipitation in the AFA stainless steel Fe–20Cr–30Ni–2Nb–5Al via cold working, Intermetallics (2014)

Clare Boothe Luce Professor of Engineering

1995–2000

• Linda Wilson

Clare Boothe Luce Special Graduate Fellowships

1997–1998

• Sally Annis ’97 Th’98 Th’01
• Kelly Goodwin ’97 Th’98
• Kathryn Miller-Jensen ’97 Th’98
• Susan Saalman ’97 Th’98 Th’99

1996–1997

• Jessica Brown ’96 Th’97
• Jessica Duda ’96 Th’97 Th’99
• Susan Ettinger Burkhart ‘96 Th’97 Th’98
• Amanda Maw ’96 Th’97

1995–1996

• Kalpana Bagri ’95 Th’95
• Linda Blumberg ’95 Th’96
• Pamela Brockmeier ’95 Th’96

1994–1995

• Christie Cameron ’94 Th’95
• Michelle Moore ’94 Th’95

Clare Boothe Luce Scholars

2005–2006

• Tia Hansen ’05 Th’06
• Elizabeth Hunneman ’05 Th’06
• Jaime Mazilu ’05 Th’06
• Sally Smith ’05 Th’06 Th’07
• Diana Szczepanski ’05 Th’06

2004–2005

• Kelly Cameron ’04 Th’05
• Stephanie Johns ’04 Th’05
• Carolyn Kirchner ’04 Th’05
• Julia Ott ’04 Th’05 Th’06
• Monica Thomas Th’05
• Amy Wallace ’04 Th’05

2003–2004

• Sara Atwood ’03 Th’04 Th’05
• Katherine Farmer Th’04 Th’07
• Emilie Fetscher ’03 Th’04
• Kathryn R. Lundquist ’03 Th’04
• April Mohns ’03 Th’04 Th’05
• Amanda Plagge ’03 Th’04 Th’06
• Gail Sweeney ’03 Th’04 Th’05

2002–2003

• Tucker Ballard ’02 Th’03
• Abigail Faulkner ’02 Th’03
• Emily Horrell ’02 Th’03
• Erin Morse ’02 Th’03
• Kendra Tupper ’02 Th’03