Peer-Reviewed Journal Articles

Google Scholar

Please email me at Pablo.A.Valdes@Dartmouth.edu if you have any questions or would like to request a reprint of one of the publications shown below.


2013

26. Kadoury S, Abi-Jaoudeh N, Valdes PA. Higher-order CRF tumor segmentation with discriminant manifold potentials. (Med Image Comput Comput Assist Interv. 2013 Sep;8149(Pt 1):719-726).

25. Valdes PA, Jacobs VL, Leblond F, Wilson BC, Roberts DW, Paulsen KD. System and methods for wide-field quantitative fluorescence imaging during neurosurgery. (Opt Lett. 2013 Aug 1;38(15):2786-8).

24. Sexton K, Davis SC, McClatchy D, Valdes PA, Kanick SC, Paulsen KD, Roberts DW, Pogue BW. Pulsed-light imaging for fluorescence guided surgery under normal room lighting. (Opt Lett. 2013 Sep 1;38(17):3249-52).

23. Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Simmons NE, Erkmen K, Paulsen KD, Roberts DW. 5-Aminolevulinic-Acid-Induced Protoporphyrin IX Fluorescence in Meningioma: Qualitative and Quantitative Measurements In Vivo. (Neurosurgery. 2013 Jul 24. [Epub ahead of print])

2012

22. Valdes PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative fluorescence imaging. (Sci Rep. 2012;2:798. Epub 2012 Nov 12).

21. Valdés PA, Leblond F, Jacobs VL, Paulsen KD, Roberts DW. In vivo fluorescence detection in surgery: A review of principles, methods, and applications. (Current Medical Imaging Reviews. 2012;8(3):211)


20. Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Ji S, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD. Adjuncts for Maximizing Resection: 5-ALA. (Clin Neurosurg. 2012;59:75-8).


19 . Valdés PA, Moses ZM, Kim A, Paulsen KD, Wilson BC, Roberts DW, Harris BT. Relationship between ex vivo gadolinium concentrations and 5-aminolevulinic acid-induced protoporphyrin IX levels in gliomas: a quantitative study on a relationship between protoporphyrin IX levels and blood-brain barrier breakdown. (J Neuropathol Exp Neurol. 2012 Sep;71(9):806-813).


18. Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Songbai J, Pogue BW, Lebnlond F, Tosteson TD, Wilson BC, Paulsen KD. Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid). (Neurosurg Clin N Am, 2012 Jul;23(3):371-7).


17. Valdes PA, Leblond F, Kim A, Paulsen KD, Wilson BC, Roberts DW. A spectrally-constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence guided surgery. (Opt Lett. 2012 Jun 1;37(11):1817-9).


16. Konecky SD, Owen CM, Rice T, Valdes PA, Kolste K, Wilson BC, Leblond F, Roberts DW, Paulsen KD, Tromberg BJ. Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models. (J Biomed Opt. 2012 May;17(5):0506008).

2011

15. Valdes PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW. Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. (Journal of Biomedical Optics. 2011 Oct;16(116006)).

14.Leblond F, Ovanesyan Z, Davis SC, Valdés PA, Kim A, Hartov A, Wilson BC, Pogue BW, Paulsen KD, Roberts DW. Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub-surface imaging. (Phys Med Biol. 2011 Nov 7;56(21):6823-37).

13. Jacobs VL, Valdes PA, Hickey WF, De Leo JA. Current review of in vivo GBM rodent models: emphais on the CNS-1 tumor model. (ASN Neuro. 2011 [Epub Jul 8])

12. Belden CJ, Valdes PA, Ran C Pastel DA, Harris BT, Fadul CE, Israel MA, Paulsen KD, Roberts DW. Genetics of glioblasotma: A window into its imaging and histopathologic variability. (Radiographics. 2011 Oct; 31(6): 1717-1740)

11. Valdes PA, Kim A, Bratsch M, Niu C, Moses Z, Tosteson TD, Wilson BC, Paulsen KD, Roberts DW, Harris BT. δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathological markers of malignancy in human gliomas: the need for quantitative fluorescence guided resection to identify regions of increasing malignancy. (Neuro-Oncology. 2011 Aug; 13(8): 846-856 )

10. Bekelis K, Valdes PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW. Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningniomas . (Neurosurgical Focus. 2011 May; 30(5):E8)

9. Whitson W, Valdes PA, Harris BT, Paulsen KD, Roberts DW. Confocal microscopy for the histologic fluorescence pattern of a recurrent atypical meningioma. (Neurosurgery. 2011 [Epub Mar 8])

8. Valdes PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, Tosteson T, Hartov A, Ji S, Paulsen KD, Roberts DW. Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as a surgical biomarker to guide resection procedures. (J Neurosurg. 2011. [Epub Mar 25])

  • Accompanying editorial:
    Editorial: Ikeda D, Chiocca EA. Measuring versus seeing.
    Response: Roberts DW, Valdes PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, Tosteson T, Hartov A, Ji S, Paulsen KD(J Neurosurg. 2011. [Epub Mar 25])

2010

7. Pogue BW, Gibbs-Strauss S, Valdes PA, Samkoe K, Roberts, DW, Paulsen KD. Review of Neurosurgical Fluorescence Imaging Methodologies. (IEEE Journal of Selected Topics in Quantum Electronics. 2010 Jun; 16(3): 493-505). Invited Review

6. Roberts DW, Valdes PA, Harris BT, Fontaine KM, Hartov A, Fan X, Ji S, Lollis SS, Pogue BW, Leblond F, Tosteson T, Wilson BC, Paulsen KD. Co-registered Fluorescence-Enhanced Tumor Resection of Malignant Glioma: Relationships between ALA-Induced PpIX Fluorescence, MRI Enhancement and Neuropathological Parameters. (J Neurosurg. 2010 Apr 9. [Epub ahead of pring])

5. Lollis SS , Valdes PA, Li Z, Ball P, Roberts, DW. Cause-Specific Mortality Among Neurosurgeons . (J Neurosurg. 2010 Sep; 113(3): 474-478. [Epub Feb 19])

4.

Valdes PA, Samkoe K, O’Hara J, Roberts DW, Paulsen DW, Pogue BW. Deferoxamine Iron Chelation Increases δ-aminolevulinic Acid Induced Protoporphyrin IX in Xenograft Glioma Model. (Photochem Photobiol. 2010 Mar/Apr; 86(2): 471-475. [Epub 2009 Dec 7] )

3. Leblond F, Davis SC, Valdes PA, Pogue BW. Pre-clinical Whole-Body Fluorescence Imaging: Review of Instruments, Methods, and Applications. (J Photochem Photobiol B. 2010 Jan 21;98(1):77-94. [Epub 2009 Nov 26] ). Review

2009

2. Valdes PA, Fan X, Ji S, Harris BT, Paulsen KD, Roberts, DW. Estimation of Brain Deformation for Volumetric Image Updating in Protoporphyrin IX Fluorescence-Guided Resection. (Stereotactic and Functional Neurosurgery, 2009 Nov 12;88(1):1-10. [Epub 2009 Nov 12])

2007

1. Geoghegan J.C., Valdes PA, Orem N.R., Deleault N.R., Williamson R.A., Harris B.T., Supattapone S. Selective incorporation of polyanionic molecules into hamster prions. (J Biol Chem, 2007 Dec 14;282(50):36341-53. Epub 2007 Oct 16)

 

Abstracts, Conferences, & Presentations


 

2014

28. Valdes PA, Jacobs VL, Leblond F, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative imaging system for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results. SPIE Photonics West. February 2014. San Francisco, CA.


27. Gosselin Y, Grenon JD, Berstein L, Vallieres-Riendeau MC, Valdes PA, Wilson BC, Paulsen KD, Roberts DW, Daigle O, Leblond F. Through-microscope spectroscopic excitation and emission for fluorescence molecular imaging as a tool to guide neurosurgical interventions. SPIE Photonics West. February 2014. San Francisco, CA.


26. Davis SC, Sexton KJ, Chapman S, McClatchy DB, Kanick SC, Valdes PA, Maytin EV, Hasan T, Pogue BW. Pulsed light imaging for wide-field dosimetry of photodynamic therapy in skin. SPIE Photonics West. February 2014. San Francisco, CA.


25. Kolste K, Kanick S, Valdes PA, Wilson BC, Paulsen KD, Roberts DW, Leblond F. Non-model-based approach for determining depth and concentration of deep fluorescent lesions in turbid media. SPIE Photonics West. February 2014. San Francisco, CA.

24. Mercier J, St-Arnaud K, Bernstein L, Gosselin Y, Grenon JD, Laurence A, Valdes PA, Mok K, Sadr MS, Petrecca K, Leblond F. Multimodal intraoperative optical spectroscopy probe for tissue characterization during brain tumor resection. SPIE Photonics West. February 2014. San Francisco, CA.

2012

23. Roberts DW, Valdes PA, Leblond F, Pogue B, Paulsen KD. Fluorescence- guidance in neurosurgery: fluorophores, equipment, and potential. New England Neurosurgical Society Annual Meeting. June 2012.


22. Valdes PA, Leblond F, Jacobs VL, Paulsen KD, Roberts DW. A through-microscope spectrally-resolved imaging system for quantitative fluorescence guided neurosurgery. IEEE International Symposium on Biomedical Imaging. May 2012.


21. Jacobs VL, Valdes PA, De Leo J. An open-source Matlab 3D MRI volumetric analysis software. IEEE International Symposium on Biomedical Imaging. May 2012.


20. Konecky SD, Owen CM, Rice T, Valdes PA, Kolste K, Wilson BC, Leblond F, Roberts DW, Paulsen KD, Tromberg BJ. Fluorescence optical tomography of preclinical glioma models using spatial frequency domain imaging. OSA BIOMED. April 2012.


19 . Valdes PA, Leblond F, Kolste K, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. A non-contact imaging approach for quantitative ALA-induced PpIX fluorescence guided resection. SPIE Photonics West. January 2012. Oral Presentation


18. Kolste K, Valdes PA, Paulsen KD, Roberts DW, Leblond F. Determining limitations of protoporphyrin IX for resolving depth of tumors during fluorescence-guided neurosurgery. SPIE Photonics West. January 2012. Oral Presentation

2011


17. Harris BT, Valdes PA, Moses Z, Belden CJ, Wilson BC, Paulsen KD, Roberts DW. Fluorescence guided resection of CNS tumors and ex vivo quantification of gadolinium and the fluorescent marker protoporphyrin IX. XXth World Congress of Neurology. November 2011.


16 . Valdes PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW. Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. Society for Neuro-Oncology Annual Meeting. November 2011.


15. Moses ZB, Valdes PA, Paulsen K, Harris BT, Roberts DW. Microvessel Density in Fluorescence-Enhanced Brain Tumor Resection. Congress of Neurological Surgeons Annual Meeting, 2011.


14. Harris BT, Valdes PA, Moses Z, Kim A, Niu C, Brantsch M, Wilson B, Paulsen K, Roberts DW. Correlates of Mass Spectrometric Measurements of Gadolinium in Gliomas undergoing Fluorescence Guided Resection. JNEN 70(6): 498, 2011 American Assoc Neuropathologists Annual Meeting, 2011.


13. Kolste K, Valdes PA, Wilson BC, Paulsen KD, Roberts DW, Leblond F. Adapting a neurosurgical microscope for fluorescence depth studies of protoporphyrin IX in brain tumors. Photonics North 2011. Oral Presentation

12. Valdés PA, Leblond F, Kim A, Harris BT, Wilson BC, Paulsen KD, Roberts DW. ALA-induced PpIX spectroscopy for brain tumor image-guided surgery. SPIE BIOS. January 2011

11. Kleen JK, Valdés PA, Harris BT, Holmes GL, Paulsen KD, Roberts DW. ALA-induced PpIX fluorescence in epileptogenic tissue. SPIE BIOS. January 2011

10. Leblond F, Valdés PA, Kim A, Davis SC, Ovanesyan Z, Krishnaswamy V, Wilson BC, Hartov A, Pogue BW, Paulsen KD, Roberts DW. A method for fluorescence-guided surgery providing an estimate of depth in multispectral near-infrared subsurface imaging. SPIE BIOS. January 2011

9. Kim A, Brantsch M, Niu C, Lebovitz E, Kolste K, Leblond F, Valdés PA, Paulsen KD, Roberts DW, Wilson BC. Ex-vivo fluorimetry of intracranial tumor biopsies excised during fluorescence-guided resection and implications for intra-operative instrument sensitivity. SPIE BIOS. January 2011

2010

8. Belden C, Valdés PA, Ran C, Harris B, Roberts D, Israel M, Paulsen K, Pastel D. Genetics of Glioblastoma Multiforme: A Window into its Imaging and Histopathologic Variability. RSNA. November 2010.

7. Valdés PA, Leblond F, Kim A, Fan X, Wilson BC, Harris BT, Paulsen KD, Roberts DW. Sensitive intraoperative in vivo detection of endogenous biomarker fluorescence from gliomas to maximize brain tumor resection. World Molecular Imaging Conference (WMIC) 2010

6. Valdés PA, Leblond F, Kim A, Fan X, Wilson BC, Harris BT, Paulsen KD, Roberts DW. Intraoperative δ-aminolevulinic acid-induced protoporphyrin IX spectroscopic quantification and tumor margin delineation of intracranial tumors. OSA BIOMED 2010

5. Fan X, Ji S, Valdés P, Roberts DW, Hartov A, Paulsen KD. Graphical user interfaces for simulation of brain deformation in image-guided neurosurgery. SPIE Medical Imaging. February 2010

2009

4. Leblond F, Valdés PA, Fontaine K, Kepshire DS, Harris BT, Ji S, Hartov A, Roberts DW, Pogue BW, Paulsen KD. Clinical and Preclinical Methods for Imaging Endogenous Fluorescence from Gliomas. WMIC. 2009

3. Valdés PA, Harris BT, Leblond F, Fontaine KM, Ji S, Pogue BW, Hartov A, Roberts DW, Paulsen KD. Brain Tumor Resection Guided by Fluorescence Imaging and MRI Image Guidance. SPIE Medical Imaging. February 2009

2. Leblond F, Fontaine KM, Valdés PA, Ji S, Pogue BW, Hartov A, Roberts DW, Paulsen KD. Brain Tumor Resection Guided by Fluorescence Imaging. SPIE Biomedical Optics. January 2009

2008

1. Lollis S.S., Valdes P.A., Li Z.Z., Ball P.A., Roberts D.W. Cause-specific mortality among neurosurgeons. Annual Meeting, New England Neurosurgical Society. June 20, 2008.