Optical molecular imaging
Optical molecular imaging is being used to provide molecular guidance in cancer surgery. Fluorescent contrast agents are in pre-clinical and clinical studies to image cancer tumors in vivo, with a dual focus, first on getting more accurate information out of the tissue, and secondly to provide better information about the specificity of the molecules as markers. Systems and algorithms for diffuse fluorescence imaging of tissue are studied, both as a stand-alone system, and as coupled to magnetic resonance imaging and computed tomography imaging. Tracer kinetic modeling is also being developed to allow quantitative imaging of molecular binding in vivo.