P. Jack Hoopes

Adjunct Professor of Engineering

Professor of Surgery and Radiation Oncology, Geisel School of Medicine
Director, Surgery and Radiation Research Laboratories
Director, Center for Comparative Medicine and Research
Co-Director NCCC Cancer Nanotechnology Working Group

+1 (603) 650-5031

p.jack.hoopes@dartmouth.edu

Research Interests

Experimental cancer therapeutics including radiation, chemotherapy, hyperthermia, photodynamic therapy and nanotechnology (iron oxide nanoparticle hyperthermia cancer treatment); animal pathology; animal models; experimental surgical technology.

Education

DVM, Veterinary Medicine, Oklahoma State University 1976
PhD, Pathology and Radiation Biology, Colorado State University 1984

Research Projects

Photodynamic therapy

Photodynamic therapy

Photodynamic therapy (PDT) is a newly emerging therapy for displastic tissues, such as cancer, age-related blindness, pre-malignant transformation or psoriasis. The therapy involves the administration of a photosensitizing agent, together with the application of moderate intensity light to active the molecules to produce local doses of singlet oxygen. Ongoing research topics include, developing improved dosimetry instrumentation and software, fluorescence tomography imaging to sense drug localization, and assaying unique tumor biology and treatment effects in experimental cancers.
Magnetic nanoparticle dosimetry

Magnetic nanoparticle dosimetry

Magnetic nanoparticle dosimetry is relevant to ongoing research in anti-cancer therapies that use magnetic nanoparticles to selectively target and destroy tumors. This study aims to utilize optical approaches to describe the distribution of these anti-cancer nanoparticles within tissue during treatments. This information is critical to interpreting treatment outcomes and optimizing patient-specific treatment schedules.