Related Links

• Laboratory
• GlycoFi, Inc.
• ADiMaB, Inc.

Tillman U. Gerngross

Professor of Engineering
603/646-3161
Tillman.Gerngross@Dartmouth.edu

Education

• B.S./M.S., Chemical Engineering, Technical University of Vienna, Austria 1989
• Ph.D., Molecular Biology, Technical University of Vienna, Austria 1991

Research Interests

Protein engineering; glycoprotein engineering; high cell density fermentation technology; metabolic engineering; protein expression.

Current Research Projects

• Cell-based protein purification systems
• Cellular engineering of protein expression hosts
• Fermentation processes
• Glyco-engineering of proteins
• Humanization of glycosylation in yeast
• Novel protein expression systems
• Resource and environmental analysis

Teaching, 2008-2010

• ENGS 35 Biotechnology and Biochemical Engineering (course description)
• ENGS 160 Biotechnology and Biochemical Engineering (course description)
• ENGS 161 Metabolic Engineering (course description)
• ENGM 189 Topics in Engineering Management: Trends in Biotechnology (course description)

Entrepreneurial

• Co-founder and scientific advisory board chair, GlycoFi Inc.
• Co-founder and CEO, ADiMaB, Inc.

Selected Publications

• Hamilton, S.R., R.C. Davidson, N. Sethuraman, J.H. Nett, Y. Jiang, S. Rios, P. Bobrowicz, T.A. Stadheim, H. Li, B-K. Choi, D. Hopkins, H. Wischnewski, J. Roser, T. Mitchell, R.R. Strawbridge, J. Hoopes, S. Wildt, T.U. Gerngross. Humanization of Yeast to Produce Complex Terminally Sialylated Glycoproteins. Science, 313(5792):1441-1443 (2006) (Abstract, Full Text Version)

• Li, H., N. Sethuraman, T.A. Stadheim, D. Zha, B. Prinz, N. Ballew, P. Bobrowicz, B-K. Choi, W.J. Cook, M. Cukan, N.R. Houston-Cummings, R. Davidson, B. Gong, S.R. Hamilton, J.P. Hoopes, Y. Jiang, N. Kim, R. Mansfield, J.H. Nett, S. Rios, R.l. Strawbridge, S. Wildt, T.U. Gerngross. Optimization of humanized IgGs in glycoengineered Pichia pastoris. Nature Biotechnology. 24, 210 - 215 (2006)

• Hamilton, S.R., H. Li, H. Wischnewski, A. Prasad, J.S. Kerley-Hamilton, T. Mitchell, A.J. Walling, R.C. Davidson, S. Wildt, and T.U. Gerngross. Intact {alpha}-1,2-endomannosidase is a typical type II membrane protein. Glycobiology. 15(6):615-24 (2005)

• Wildt, S., and T.U. Gerngross. The humanization of N-glycosylation pathways in yeast. Nature Reviews Microbiol. 3(2):119-28 (2005)

• Gerngross, T.U., Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nature-Biotechnology, pp1409 -1414 (2004)

• Hamilton, S.R., P. Bobrowicz, B. Bobrowicz, H. Li, T. Mitchell, J.H. Nett, S. Rausch, T.A. Stadheim, S. Wildt, H. Wischnewski, and T.U. Gerngross. Production of complex human glycoproteins in yeast. Science, 301, 1244 (2003) (Abstract, Full Text Version)

Press Releases

• Engineering profs chosen as NH "Entrepreneurs of the Year" (posted 6/01/07)

• Dartmouth and GlycoFi Report Full Humanization of Therapeutic Proteins from Yeast (posted 9/8/06)

• Merck & Co., Inc. to Acquire GlycoFi, Inc. (posted 5/9/06)

• Merck & Co., Inc. to Acquire GlycoFi, Inc. (posted 5/9/06)

• Dartmouth Bioengineers Develop Humanized Yeast (posted 8/28/03)

• Dartmouth engineers closer to mass-producing therapeutic proteins (posted 4/17/03)

• Dartmouth researchers put recycling in perspective (posted 3/7/03)

• Dartmouth Engineering Professors Secure $7 Million in Venture Capital for GlycoFi, Inc. (posted 5/20/02)

In the News

• Scientific American
  September 7, 2006
  "Have Some Sugar with Your Protein; A Tiny Company Engineers Yeast to Make Better Human Therapeutics, a Technique that Could Transform Biotech Manufacturing"
  By Gary Stix

• Red Herring
  September 7, 2006
  "GlycoFi Gets Its Crown Jewel" (subscription required)

• Chemical & Engineering News
  September 4, 2006
  "Glycosylation Engineering; Controlling Personalities Tame Wild Sugars on Proteins and Natural Products"
  By Stu Borman

• The Boston Globe
  May 10, 2006
  GlycoFi in "Merck to buy N.H. biotech in record bid"
  By Stephen Heuser

• Nature Biotechnology
  March 2, 2006
  In "Who's who in biotech" (subscription required)
  Professor Gerngross is shortlisted by the editors of Nature Biotechnology, amongst personalities who have made the most significant contribution to biotech in the past 10 years.

• Scientific American
  January 23, 2006
  GlycoFi in Yeast Builds Better Monoclonal Antibodies

• Chemical & Engineering News, 83(32)
  August 8, 2005
  "Carbohydrate Advances"
  By Stu Borman

• Los Angeles Times
  June 26, 2005
  "To Replace Oil, U.S. Experts See Amber Waves of Plastic; American Crops Could be Used in Place of Many Products' Petroleum Base, Some Scientists Say"
  By Stephanie Simon

• The Seattle Times
  June 26, 2005
  "Factories turning corn into plastics"

• Scientific American
  November 11, 2004
  The 2004 Scientific American 50 Award: Business Leaders recognizes GlycoFi for outstanding technology leadership in manufacturing

• BioMedNet Gateways and News
  January 15, 2004
  "Yeast gets humanized"
  By Henry Nicholls

• Scientific American
  January, 2004
  "Supercharging Protein Manufacture"
  By Gary Stix

• Chemical and Engineering News
  December 22, 2003
  "Bioengineering"
  By Stu Borman

• Nature Biotechnology—bioentrepreneur
  November 24, 2003
  Startup Profiles: Glycofi—"Making drugs in yeast"
  By Laura DeFrancesco

• Dartmouth Medicine
  Fall 2003
  "Sugar is Sweet ..."
  By Laura Stephenson Carter

• Die Welt
  September 1, 2003
  "Hefepilze sollen empfindliche Hamsterzellen ersetzen"

• The Washington Times
  August 29, 2003
  "Genetically Engineered Yeast Boon To Biotech"
  By Peggy Peck

• BBC News
  August 29, 2003
  "Yeast turned into drugs factory"

• Nature
  August 29, 2003
  "Humanised yeast produce healing proteins"
  By Helen Pearson

• New Scientist
  August 29, 2003
  "Modified yeast produces fully human proteins"
  By Gaia Vince

• The Guardian, London
  August 29, 2003
  "Researchers tweak yeast DNA to produce human protein"
  By Tim Radford

• Science
  August 29, 2003
  "Yeast Engineered to Produce Sugared Human Proteins" (subscription required)
  By Robert F. Service

• Scientific American
  July, 2003
  "Sugar Added: Cheaper, better protein drugs through sweetening" (subscription required)
  By W. Wayt Gibbs

• New Scientist
  April 26, 2003
  "How a sweeter kind of yeast will make hundreds of drugs more effective"
  By Andy Coghlan

• Science
  February 7, 2003
  "Biopolymers and the Environment" (subscription required)
  By Tillman Gerngross and Steven Slater

• Scientific American
  August 2000
  "How Green Are Green Plastics?"
  By Tillman U. Gerngross and Steven C. Slater

• Nature Biotechnology
  May 2000, vol. 18, p. 490
  "Analysis: Experts disagree over color of biomass"
  By Alan Dove

• Scientific American
  April 2000
  "Car Parts from Chickens" (subscription required)
  By Diane Martindale

• Boston Globe
  September 26, 1999
  "Using Plants to Make Plastics Eats Up Energy, Study Says"
  By Robert Braile

• The Economist
  September 11th-17th, 1999
  "Fantastic plastic"

• CNN.com
  August 27, 1999
  "Plastic from plants called costly"

• Environmental News Network
  August 25, 1999
  "Plastic from plants called costly"

• London Times
  June 23, 1999
  "The myth of 'green' plastic"
  By Nigel Hawkes