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Karl Griswold

Karl Griswold

Assistant Professor of Engineering
603/646-2127
Karl.E.Griswold@Dartmouth.edu

Education

  • Ph.D., Chemistry, University of Texas at Austin 2005
  • B.S., Chemistry, Southwest Texas State University 1995

Research Interests

Protein engineering; directed evolution; biotherapeutics; applied biocatalysis; high throughput screening.

Current Research Projects

Teaching, 2009-2011

Selected Publications

  • Zheng, W., Griswold, K.E., Bailey-Kellogg, C. Protein fragment swapping: A method for asymmetric, selective site-directed recombination. Proceedings of the 13th Annual International Conference on Research in Computational Molecular Biology (2009) pp. 321-338.

  • Griswold, K.E., Aiyappan, N.S., Iverson, B.L., Georgiou, G. The Evolution of Catalytic Efficiency and Substrate Promiscuity in Human Theta Class 1-1 Glutathione Transferase. Journal of Molecular Biology (2006), 364(3), 400-10.

  • Griswold, K.E., Kawarasaki, Y., Ghoneim, N., Benkovic, S.J., Iverson, B.L., Georgiou, G. Evolution of highly active enzymes by homology-independent recombination. Proceedings of the National Academy of Sciences, USA (2005), 102(29), 10082-7

  • Levy, M., Griswold, K.E., Ellington, A.D. Direct selection of trans-acting ligase ribozymes by in-vitro compartmentalization. RNA (2005), 11(10):1555-62

  • Griswold, K.E. pH sensing agar plate assays for esterolytic enzyme activity. Methods in Molecular Biology (Totowa, NJ, United States) (2003), 230, 203-11

  • Griswold, K.E., Mahmood, N.A., Iverson, B.L., Georgiou, G. Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm. Protein Expression and Purification (2003), 27(1), 134-42

Awards

  • Wallace H. Coulter Foundation Early Career Translational Research Award in Biomedical Engineering (2008)
  • NIH Biotechnology Training Grant (2000-2003)
  • Royston M. Roberts - Regents Fellowship, University of Texas (1999)
  • DOW Chemical Foundation Scholar, Texas State University (1991-1995)
  • Presidential Upper Division Scholar, Texas State University (1994-1995)
  • ACS Polymer Education Committee Award for Organic Chemistry (1993)

Selected Patent

  • Griswold, Karl E. Primary alkanolamides, their preparation and their uses. PCT Int. Appl. (2000), 23 pp. CODEN: PIXXD2 WO 2000066543 A1 20001109 CAN 133:335966 AN 2000:790464 CAPLUS

Professional Activities

  • Member, AIChE
  • Member, ACS
  • Member, SIM
  • Member, ASEE

Press Releases

In the News

  • The Journal News (NY)
    March 31, 2008
    "Hundreds of students attend annual Engineering Expo at Tappan Zee High School in Orangeburg"

In Dartmouth Engineer Magazine