Karl Griswold
Assistant Professor of Engineering
603/646-2127
Karl.E.Griswold@Dartmouth.edu
Education
- Ph.D., Chemistry, University of Texas at Austin 2005
- B.S., Chemistry, Southwest Texas State University 1995
Research Interests
Protein engineering; directed evolution; biotherapeutics; applied biocatalysis; high throughput screening.
Current Research Projects
Teaching, 2007-2009
- ENGS 158 Chemical Kinetics and Reactors (course description)
Selected Publications
Griswold, K.E., Aiyappan, N.S., Iverson, B.L., Georgiou, G. The Evolution of Catalytic Efficiency and Substrate Promiscuity in Human Theta Class 1-1 Glutathione Transferase. Journal of Molecular Biology (2006), 364(3), 400-10.
Griswold, K.E., Kawarasaki, Y., Ghoneim, N., Benkovic, S.J., Iverson, B.L., Georgiou, G. Evolution of highly active enzymes by homology-independent recombination. Proceedings of the National Academy of Sciences, USA (2005), 102(29), 10082-7
Levy, M., Griswold, K.E., Ellington, A.D. Direct selection of trans-acting ligase ribozymes by in-vitro compartmentalization. RNA (2005), 11(10):1555-62
Griswold, K.E. pH sensing agar plate assays for esterolytic enzyme activity. Methods in Molecular Biology (Totowa, NJ, United States) (2003), 230, 203-11
Griswold, K.E., Mahmood, N.A., Iverson, B.L., Georgiou, G. Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm. Protein Expression and Purification (2003), 27(1), 134-42
Awards
- NIH Biotechnology Training Grant (2000-2003)
- Royston M. Roberts - Regents Fellowship, University of Texas (1999)
- DOW Chemical Foundation Scholar, Texas State University (1991-1995)
- Presidential Upper Division Scholar, Texas State University (1994-1995)
- ACS Polymer Education Committee Award for Organic Chemistry (1993)
Selected Patent
- Griswold, Karl E. Primary alkanolamides, their preparation and their uses. PCT Int. Appl. (2000), 23 pp. CODEN: PIXXD2 WO 2000066543 A1 20001109 CAN 133:335966 AN 2000:790464 CAPLUS
Professional Activities
- Member AIChE
- Member ACS
Press Releases
In the News
- The Journal News (NY)
March 31, 2008
"Hundreds of students attend annual Engineering Expo at Tappan Zee High School in Orangeburg"