Raman Spectroscopy of Bone and Cartilage: A Multidisciplinary Approach to Understanding Development, Function, and Disease

Michael Morris, University of Michigan

Friday, November 21, 2008

Spanos Auditorium

This seminar is part of the Jones Seminars on Science, Technology, and Society series

We will briefly review the biology, structure and function of bone and cartilage and describe osteoporosis and osteoarthritis, two major disorders that can incapacitate their victims if left untreated. These diseases now cost the U.S. tens of billions of dollars annually. After a short introduction to the technology, we will show how Raman spectroscopy contributes to almost every aspect of study of musculoskeletal tissue structure, function and disease diagnosis. The contributions of spectroscopy and spectroscopists range from illuminating the mechanism by which bone is mineralized, through elucidation of the chemical changes accompanying exercise and aging to development of new non-invasive and minimally invasive diagnostics for bone and cartilage diseases. Throughout we will emphasize how progress in musculoskeletal tissue science and medicine requires teams of chemists, biologists, biomedical engineers and clinicians.

About the Speaker

Michael D. Morris is professor of chemistry and an affiliated member of the university's Biomedical Engineering faculty and Comprehensive Cancer Center. He is a pioneer in applied Raman spectroscopy, particularly in its uses in microscopy and imaging. He has made important contributions to instrumentation and to computational techniques for Raman image processing and three-dimensional Raman imaging. In the last ten years his laboratory has developed Raman spectroscopy for study of musculoskeletal tissues. He and his co-workers have published on mechanisms of tissue mineralization, biomechanical properties of bone and spectroscopic assessment of bone and cartilage health. For his work Morris has received national awards from the Society, for Applied Spectroscopy, the Federation of Analytical Chemistry and Spectroscopy Societies and the American Chemical Society.