Defense of Thesis Proposal: Bradley Ficko

Monday, November 4, 2013, 1:00pm

Jackson Conference Room

"AC Susceptibility Imaging of Magnetic Nanoparticles for Hyperthermia Cancer Therapy"

Thesis Committee:
Solomon Diamond, Ph.D. (Chair)
Richard Greenwald, Ph.D.
Alexander Hartov, Ph.D.
P. Jack Hoopes, D.V.M., Ph.D.
Donglu Shi, Ph.D

Abstract: Magnetic nanoparticles (mNPs) have an increasing number of applications in cancer therapy. Hyperthermia is one such application where the mNPs are used to help treat cancer through targeted heating of tumors. In this therapy, mNPs are exposed to a high frequency alternating magnetic field that heats the mNPs depending on their type and in proportion to their concentration. Hyperthermia has shown efficacy as a stand-alone or adjuvant therapy in animal studies. To achieve heating, mNPs must be delivered to and retained inside tumors. However, due to the potential for mNP dispersion outside of the targeted tumor and risk of damage to healthy tissues, clinical trials need to be conducted with real time image guidance. The focus of this proposed doctoral thesis is to develop an imaging system for mNP hyperthermia therapy that can provide clinically useful real-time imaging of mNPs.

A bench top proof-of-concept prototype has been successfully built and tested to demonstrate the functionality of the proposed mNP imaging approach. The performance of the prototype was measured through a series of experiments designed to evaluate its performance characteristics and to identify the challenges that are likely to arise when increasing the density of the imaging array. Magnetic susceptibility magnitude images showed a contrast-to-noise ratio of 23 for 0.5 ml of 12.5 mg Fe/ml mNPs at 1 cm depth. AC susceptibility images showed the in-phase and out-of-phase susceptibility of three mNP samples of 10, 40 and 100 nm and using spectroscopic imaging it was possible to determine the concentration of each mNP sample in each imaging voxel (R2= 0.97). These results indicate that the proposed mNP imaging approach can potentially be extended to a larger, higher-resolution clinical imaging system.

For more information, contact Daryl Laware at daryl.a.laware@dartmouth.edu.